alaS

alaS
168

alanine-tRNA synthetase

Locus
BSU_27410
Molecular weight
97.08 kDa
Isoelectric point
4.92
Protein length
878 aaSequenceBlast
Gene length
2637 bpSequenceBlast
Function
translation
Product
alanine-tRNA synthetase
Essential
yes
E.C.
6.1.1.7
Synonyms
alaS
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0013 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,798,174  2,800,810
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
ATP + L-alanine + tRNAAla --> AMP + diphosphate + L-alanyl-tRNAAla (according to UniProt)
Protein family
Class-II aminoacyl-tRNA synthetase family (according to UniProt)
Structure
1YFS (PDB) (enzyme from Aquifex aeolicus) PubMed
3HXU (PDB) (enzyme from E. coli with alanine) PubMed
O34526 (AlphaFold)
Expression and Regulation
Operons
Genes
alaS-reoM-yrrK-yrzB
Description
PubMed
Regulation
induced by alanine limitation ([regulon|T-box|]) PubMed
Regulatory mechanism
T-box: RNA switch, [pubmed|], in T-box
Open in new tab

alaS->yrzB

2025-04-04 06:40:58

Bzhu

123

1fe3dcf0db8626f9ee3da1f804086613bec215b9

F35CA2CD94C7D88BA9469B9BEE16089909E658A6

Biological materials
Two-hybrid system
B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Jörg Stülke's lab
References
Loading

8C5C7F9A585AE89D53EAF1DB3A9AB525B9E30B4A

Page visits: 4626

Time of last update: 2025-04-13 10:20:26

Author of last update: Jstuelk