infB
168
translation initiation factor IF-2, ribosome-dependent GTPase interacting with 30 ribosome subunits, ensures correct binding of initiator tRNAs
Locus
BSU_16630
Molecular weight
78.35 kDa
Isoelectric point
5.19
Function
translation
Product
initiation factor IF-2
Essential
yes
Synonyms
infB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0532 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
The protein
Catalyzed reaction/ biological activity
ribosome-dependent GTPase interacting with 30 ribosome subunits, ensures correct binding of initiator tRNAs PubMed
Putative cellular metabolic sensor and regulator that oscillates between an active GTP-bound form under conditions allowing active protein syntheses and an inactive ppGpp-bound form when depleting of nutrients PubMed
Protein family
TRAFAC class translation factor GTPase superfamily (according to UniProt)
Classic translation factor GTPase family (according to UniProt)
Nucleotide-binding domain that competitively binds GTP or ppGpp PubMed
tr-type G domain (aa 217-386) (according to UniProt)
Structure
1D1N (PDB) (fMet-tRNA-fMet binding domain, Geobacillus stearothermophilus), 1Z9B (PDB) (C1-subdomain, Geobacillus stearothermophilus)
Effectors of protein activity
GTP and ppGpp PubMed
cytoplasm (according to UniProt)
Expression and Regulation
Operons
Description
Regulation
induced by glucose PubMed
expression is reduced in motile cells as compared to non-motile cells PubMed
Regulatory mechanism
stringent response: negative regulation, in stringent response
Sigma factors
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References
Reviews
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Original Publications
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Time of last update: 2025-04-06 14:20:07
Author of last update: Jstuelk