rplB
168
ribosomal protein uL2, required for assembly of RplP into the 50S subunit of the ribosome
Locus
BSU_01190
Molecular weight
30.18 kDa
Isoelectric point
11.01
Function
translation
Product
ribosomal protein L2 (uL2)
Essential
yes
Synonyms
rplB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0090 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
137,311 138,144
Phenotypes of a mutant
essential PubMed
a H142L mutation results in a temperature-sensitive phenotype and is acompanied by growth and sporulation defects, the mutation can be suppressed by increased expression of ''yaaA'' PubMed
The protein
Protein family
universal ribosomal protein uL2 family (single member, according to UniProt)
Structure
1RL2 (PDB) (L2 RNA-binding domain, Geobacillus stearothermophilus)
Expression and Regulation
Operons
Genes
Description
Regulation
strongly repressed in response to glucose starvation in M9 medium PubMed
likely autorepression of operon expression upon binding of excess of one ribosomal protein to the untranslated region of the mRNA PubMed
expression is reduced in motile cells as compared to non-motile cells PubMed
Regulatory mechanism
stringent response: negative regulation, in stringent response
Sigma factors
SigA: sigma factor, PubMed (two promoters, about 140bp and 200bp upstream of the start codon), in sigA regulon
Additional information
term-seq has identified a potential novel regulatory RNA element (protein-dependent leader) including an intrinsic transcription terminator upstream of rpsJ PubMed
References
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Time of last update: 2025-04-06 09:52:07
Author of last update: Jstuelk