drm

drm
168

phosphopentomutase

Locus
BSU_23500
Molecular weight
43.77 kDa
Isoelectric point
4.97
Protein length
394 aaSequenceBlast
Gene length
1185 bpSequenceBlast
Function
utilization of deoxyribose
Product
phosphopentomutase
Essential
no
E.C.
5.4.2.7
Synonyms
drm, yqkN
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1015 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,447,246  2,448,430
The protein
Catalyzed reaction/ biological activity
α-D-ribose 1-phosphate --> D-ribose 5-phosphate (according to UniProt)
2-deoxy-α-D-ribose 1-phosphate --> 2-deoxy-D-ribose 5-phosphate (according to UniProt)
Protein family
phosphopentomutase family (single member, according to UniProt)
Structure
3M8W (PDB) (from B. cereus, 77% identity, 86% similarity) PubMed
P46353 (AlphaFold)
Modification
phosphorylation on (Thr-87 OR Thr-89) PubMed
CoA is attached to Cys-233 in spores PubMed
Expression and Regulation
Operons
Genes
drm-pupG
Description
PubMed
Regulation
induced in the presence of nucleosides (deoxyribose 5-phosphate and ribose 5-phosphate act as molecular inducers) PubMed
Regulatory mechanism
CcpA: repression, PubMed, in ccpA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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drm→pupG

2025-03-14 18:40:59

ghost

90

14c764b577f7631beda537db900a102a9f367490

F338011D0443A78E516CD55DF097CFDB8967EE05

Biological materials
Mutant
BKE23500 (drm::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTTGAAAGCCTCCTTTT,  downstream forward: _UP4_TAGGGGGACTGTTTCTTGAA
BKK23500 (drm::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTTGAAAGCCTCCTTTT,  downstream forward: _UP4_TAGGGGGACTGTTTCTTGAA
References
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Page visits: 4816

Time of last update: 2025-04-10 08:38:28

Author of last update: Jstuelk