tcyC

tcyC
168

cystine and diaminopimelate ABC transporter, ATP-binding protein

Locus
BSU_03590
Molecular weight
27.64 kDa
Isoelectric point
7.19
Protein length
247 aaSequenceBlast
Gene length
744 bpSequenceBlast
Function
cystine and diaminopimelate uptake
Product
cystine and diaminopimelate ABC transporter, ATP-binding protein
Essential
no
Synonyms
tcyC, yckI
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1126 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
409,208 → 409,951
The protein
Catalyzed reaction/ biological activity
uptake of cystine and diaminopimelate PubMed
Protein family
ABC transporter superfamily (according to UniProt)
L-cystine importer (TC 3.A.1.3.14) family (single member, according to UniProt)
Domains
ABC transporter domain (aa 2-240) (according to UniProt)
Structure
2Q0H (PDB) (in complex with ADP-Mg2+, Geobacillus stearothermophilus, 55% identity)
P39456 (AlphaFold)
Paralogous protein(s)
YxeO, PstBB, YvrO, GlnQ, ArtR, TcyN, PstBA
Localization
attached to the membrane via TcyB PubMed
Expression and Regulation
Operons
Genes
tcyA-tcyB-tcyC
Description
PubMed
Regulation
strongly repressed in response to glucose starvation in M9 medium PubMed
Open in new tab

tcyA→tcyC

2025-03-28 06:06:34

Jstuelk

123

4d611b63f86c92d9ecb8c2daaa53e692acd195f5

768128284DD011A0C571EBC11696DA21513C3B17

Biological materials
Mutant
MGNA-C004 (yckI::erm), available at the NBRP B. subtilis, Japan
BKE03590 (ΔtcyC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AACGGTAAGCATACTCGGAA,  downstream forward: _UP4_TAATAAGAAAAACAGAGCGT
BKK03590 (ΔtcyC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AACGGTAAGCATACTCGGAA,  downstream forward: _UP4_TAATAAGAAAAACAGAGCGT
References
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Time of last update: 2025-04-10 11:10:56

Author of last update: Melvin.boenninger