copA

copA
168

copper-exporting ATPase, resistance to copper

Locus
BSU_33500
Molecular weight
85.83 kDa
Isoelectric point
5.48
Protein length
803 aaSequenceBlast
Gene length
2409 bpSequenceBlast
Function
copper export, detoxification
Product
copper transporting ATPase
Essential
no
Synonyms
copA, yvgX
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2608 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,441,121 → 3,443,529
The protein
Catalyzed reaction/ biological activity
ATP + Cu+ + H2O --> ADP + Cu+ + H+ + phosphate (according to UniProt)
Protein family
cation transport ATPase (P-type) (TC 3.A.3) family (according to UniProt)
Domains
two N-terminal soluble domains, CopAa and CopAb, connected by a short linker PubMed
2 HMA domains (aa 6-72, aa 74-140) (according to UniProt)
Structure
4BBJ (PDB) (the protein from Legionella pneumophila, 45% identity, 79% similarity) PubMed
2RML (PDB) ( N-terminal soluble domain) PubMed
O32220 (AlphaFold)
Paralogous protein(s)
PfeT, CadA
Localization
cell membrane (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
csoR-copZ-copA
Description
PubMed
Open in new tab

csoR→copA

2025-04-04 08:09:55

Jstuelk

95

eb86b49e4fa20367c75145f1a228f37db4b5da04

AAFF284B2BD1673523D4C48EA1D3231D7A156AFC

Genes
copZ-copA
Description
PubMed
Regulation
induced by copper (CsoR) PubMed
Regulatory mechanism
CsoR: repression, PubMed, in csoR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

copZ→copA

2025-04-04 07:59:45

ghost

127

82e064a450e42e8934b8717c092adbe5ec47123b

C1EEB785789E5FED12C2A62EF4EB3404C7EFF35B

Biological materials
Mutant
MGNA-A490 (yvgX::erm), available at the NBRP B. subtilis, Japan
BKE33500 (ΔcopA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAACATACTCACTCCTTTAT,  downstream forward: _UP4_TGAAAAACCGGCTATATGCC
BKK33500 (ΔcopA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAACATACTCACTCCTTTAT,  downstream forward: _UP4_TGAAAAACCGGCTATATGCC
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
References
Reviews
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Original Publications
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727024F7B1AC19676ED4B516CF46A47B1328310B

Page visits: 4391

Time of last update: 2025-04-10 12:02:31

Author of last update: Jstuelk