comC

comC
168

late competence gene required for processing and translocation of ComGC, ComGD, ComGE and ComGG

Locus
BSU_28070
Molecular weight
26.37 kDa
Isoelectric point
9.84
Protein length
248 aaSequenceBlast
Gene length
747 bpSequenceBlast
Function
genetic competence
Product
processing protease
Essential
no
E.C.
null
Synonyms
comC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1989 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,864,426  2,865,172
The protein
Catalyzed reaction/ biological activity
processing and translocation of ComGC, ComGD, ComGE and ComGG PubMed
Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine (according to UniProt)
Protein family
peptidase A24 family (single member, according to UniProt)
Structure
P15378 (AlphaFold)
Localization
integral membrane protein PubMed
Expression and Regulation
Operons
Genes
comC
Description
PubMed
Regulatory mechanism
ComK: activation, PubMed, in comK regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

comC

2025-03-12 12:10:51

ghost

59

ec9f472ccea50878711db77008ba6125413fcd08

CBA99585D8C8A38651714AE78AC8575F5495D627

Biological materials
Mutant
BKE28070 (comC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAGACAACACACCTTTAC,  downstream forward: _UP4_TGACTGCTGAAAAATTTGAC
BKK28070 (comC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAGACAACACACCTTTAC,  downstream forward: _UP4_TGACTGCTGAAAAATTTGAC
References
Reviews
Loading
Original Publications
Loading

57FDE2ABB5E9773717C23D727FD6CDA5D8CC3E36

Page visits: 4353

Time of last update: 2025-04-16 11:21:16

Author of last update: Jstuelk