walH
168

negative effector of WalK, controls cell wall metabolism

Locus

BSU_40390

Molecular weight

52.05 kDa

Isoelectric point

5.59

Protein length

455 aaSequenceBlast

Gene length

1368 bpSequenceBlast

Function

control of cell wall metabolism

Product

negative effector of WalK

Essential

Synonyms

walH, yycH

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

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Categories containing this gene/protein

List of homologs in different organisms, belongs to COG4863 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

4,150,496 4,151,863

Phenotypes of a mutant

growth defect at high temperature, lysis at 49C, this can be suppressed by mutations that reduce WalK autokinase activity, by inactivation of lytE, or by overexpreesion of IseA or PdaC PubMed

defective in Swarming motility (periodic cessation and reinitiation of Swarming motility, terracing colonies) PubMed

Additional information

the gene readily acquires mutations during cultivation with Arabidopsis thaliana roots PubMed

The protein

Structure

2FGT (PDB)

Q794W0 (AlphaFold)

Localization

cell membrane (according to UniProt), spotty close to the membrane PubMed

Expression and Regulation

Operons

Genes

walR-walK-walH-walI-walJ-htrC

Description

PubMed

Regulation

htrC transcript expressed during sporulation PubMed

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Biological materials

Mutant

MGNA-B826 (yycH::erm), available at the NBRP B. subtilis, Japan

BKE40390 (walH::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CGTAAGTAATATCGTTTTTA, downstream forward: _UP4_TTATTGAGGAAGGAGGGGGC

BKK40390 (walH::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CGTAAGTAATATCGTTTTTA, downstream forward: _UP4_TTATTGAGGAAGGAGGGGGC

References

Reviews

Original Publications

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Time of last update: 2025-04-02 18:59:16

Author of last update: Jstuelk

walH 168

walH
168