iolR

iolR
168

transcriptional repressor of the iol operon, DeoR family

Locus
BSU_39770
Molecular weight
28.25 kDa
Isoelectric point
6.33
Protein length
251 aaSequenceBlast
Gene length
756 bpSequenceBlast
Function
regulation of myo-inositol catabolism
Product
transcriptional repressor
Essential
no
Synonyms
iolR
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1349 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
4,084,799  4,085,554
Phenotypes of a mutant
inactivation of ''iolR'' reduces sporulation efficiency to 38% that of wild type cells PubMed
The protein
Domains
HTH deoR-type domain (aa 1-57) (according to UniProt)
Structure
P46337 (AlphaFold)
Effectors of protein activity
inducer: 2-deoxy-5-keto-D-gluconic acid-6-phosphate
Expression and Regulation
Operons
Genes
iolR-iolS
Description
PubMed
Regulation
induced by inositol (IolR) PubMed
Regulatory mechanism
IolR: repression, PubMed, in iolR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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iolR→iolS

2025-04-10 03:17:16

ghost

88

8770699e2835badc7cbf5c9c4652defe40d236e1

FD73AC3FBA5FCDBE2F4BF70EFC6DCFA35CB11689

Biological materials
Mutant
BKE39770 (iolR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATAAAAAACTCCTTCTT,  downstream forward: _UP4_TAACGTTTACAATAGTGTTG
BKK39770 (iolR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATAAAAAACTCCTTCTT,  downstream forward: _UP4_TAACGTTTACAATAGTGTTG
Labs working on this gene/protein
Yasutaro Fujita, University of Fukuyama, Japan
[[Ken-ichi Yoshida]], Kobe University, Japan
References
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5F4ABBC8ECAD6F6C10EC39B2B0F0BC73F11522CE

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Time of last update: 2025-04-13 07:12:41

Author of last update: Melvin.boenninger