iolI
168

inosose isomerase, converts 2KMI to 1-keto-D-chiro-inositol

Locus

BSU_39680

Molecular weight

31.50 kDa

Isoelectric point

4.66

Protein length

278 aaSequenceBlast

Gene length

837 bpSequenceBlast

Function

myo-inositol catabolism

Product

inosose isomerase, converts 2KMI to 1-keto-D-chiro-inositol

Essential

E.C.

null

Synonyms

iolI, yxdH

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1082 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

4,073,974 4,074,810

The protein

Catalyzed reaction/ biological activity

2,4,6/3,5-pentahydroxycyclohexanone --> 2,3,5/4,6-pentahydroxycyclohexanone (according to UniProt)

scyllo-inosose --> scyllo-inosine (according to UniProt)

Protein family

IolI family (single member, according to UniProt)

Structure

1L60 (PDB)

P42419 (AlphaFold)

Expression and Regulation

Operons

Genes

iolA-iolB-iolC-iolD-iolE-iolF-iolG-iolH-iolI-iolJ

Description

PubMed

Regulation

induced by inositol (IolR) PubMed

Regulatory mechanism

IolR: repression, PubMed, in iolR regulon

CcpA: repression, PubMed, in ccpA regulon

Sigma factors

SigA: sigma factor, PubMed, in sigA regulon

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Biological materials

Mutant

MGNA-B700 (iolI::erm), available at the NBRP B. subtilis, Japan

BKE39680 (iolI::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGCCAGACTCCCCCATCT, downstream forward: _UP4_TAATGGATAAAGGAGGGGTG

BKK39680 (iolI::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGCCAGACTCCCCCATCT, downstream forward: _UP4_TAATGGATAAAGGAGGGGTG

Labs working on this gene/protein

Yasutaro Fujita, University of Fukuyama, Japan

[[Ken-ichi Yoshida]], Kobe University, Japan

References

Page visits: 2514

Time of last update: 2025-04-13 16:36:44

Author of last update: Melvin.boenninger

iolI 168

iolI
168