clsA

clsA
168

cardiolipin synthase, major enzyme

Locus
BSU_36590
Molecular weight
55.70 kDa
Isoelectric point
9.55
Protein length
482 aaSequenceBlast
Gene length
1449 bpSequenceBlast
Function
biosynthesis of phospholipids
Product
cardiolipin synthase, major enzyme
Essential
no
Synonyms
clsA, ywnE
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1502 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,762,664  3,764,112
Phenotypes of a mutant
increased conjugation of ICEBs1 PubMed
The protein
Catalyzed reaction/ biological activity
2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) --> cardiolipin + glycerol (according to UniProt)
Protein family
phospholipase D family (with YwjE and YwiE, according to UniProt)
Domains
2 PLD phosphodiesterase domains (aa 217-244, aa 395-422) (according to UniProt)
Structure
P71040 (AlphaFold)
Paralogous protein(s)
YwjE, YwiE
Localization
cell membrane at the septum, this localization depends on two C-terminal helices PubMed
Expression and Regulation
Operons
Genes
clsA
Description
PubMed
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clsA

2025-02-22 08:01:21

Jstuelk

57

17b5e993fc4ae8efda73aaba12947ead9e4a779d

39B1663B05B6B18189A6B7359FE9134182009688

Biological materials
Mutant
BKE36590 (clsA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACTTTGTAACCCCGCTCAT,  downstream forward: _UP4_TAAGATGCGTAAACCCCCGG
BKK36590 (clsA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACTTTGTAACCCCGCTCAT,  downstream forward: _UP4_TAAGATGCGTAAACCCCCGG
References
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2079B210322F26EEC3CCF55611622FADDB1D1BC7

Page visits: 6511

Time of last update: 2025-04-10 18:40:18

Author of last update: Melvin.boenninger