tuaD

tuaD
168

UDP glucose 6-dehydrogenase

Locus
BSU_35580
Molecular weight
49.65 kDa
Isoelectric point
6.11
Protein length
461 aaSequenceBlast
Gene length
1386 bpSequenceBlast
Function
biosynthesis of teichuronic acid
Product
UDP glucose 6-dehydrogenase
Essential
no
E.C.
1.1.1.22
Synonyms
tuaD, yvhD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1004 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,654,139 → 3,655,524
The protein
Catalyzed reaction/ biological activity
H2O + 2 NAD+ + UDP-α-D-glucose --> 3 H+ + 2 NADH + UDP-α-D-glucuronate (according to UniProt)
Protein family
UDP-glucose/GDP-mannose dehydrogenase family (with YtcA and Ugd, according to UniProt)
Structure
3GG2 (PDB) (from Porphyromonas gingivalis, 48% identity)
O32271 (AlphaFold)
Modification
phosphorylation on a Tyr residue by PtkA PubMed, dephosphorylated by PtpZ PubMed
Effectors of protein activity
PtkA-dependent phosphorylation stimulates TuaD activity PubMed
Paralogous protein(s)
Ugd, YtcA
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
tuaA/2-tuaA/1-tuaB-tuaC-tuaD-tuaE-tuaF-tuaG-tuaH
Description
PubMed
Regulation
expressed during sporulation in the forespore (SigF) PubMed
Regulatory mechanism
PhoP: activation, PubMed, in phoP regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigF: sigma factor, PubMed, in sigF regulon
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tuaA/2→tuaH

2025-04-03 08:59:52

Jstuelk

117

761c7ee893d8412e202f5ec96ccf574895435d9d

E7C38AD5E6CAA14FB6A6EA9BA986E36B3BBE7E1D

Biological materials
Mutant
BKE35580 (ΔtuaD::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACAGCGCTCAACCCTCTCC,  downstream forward: _UP4_TAAAAAGAAAAAGTGTTACT
BKK35580 (ΔtuaD::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACAGCGCTCAACCCTCTCC,  downstream forward: _UP4_TAAAAAGAAAAAGTGTTACT
References
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DF8CD0B3997A7A4CF4821A7D64E9898422FD17E0

Page visits: 6255

Time of last update: 2025-04-07 05:03:27

Author of last update: Melvin.boenninger