tuaG

tuaG
168

sugar transferase

Locus
BSU_35550
Molecular weight
29.19 kDa
Isoelectric point
7.14
Protein length
252 aaSequenceBlast
Gene length
759 bpSequenceBlast
Function
biosynthesis of teichuronic acid
Product
sugar transferase
Essential
no
Synonyms
tuaG, yvhG
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms, belongs to COG0463 (Galperin et al., 2021)

This gene is a member of the following regulons

SigA regulon, SigF regulon, PhoP regulon

Gene
Coordinates
3,651,097  3,651,855
The protein
Protein family
glycosyltransferase 2 family (according to UniProt)
Structure
5TZE (PDB) (from Staphylococcus aureus, corresponds to aa 9 ... 141, 37% identity) PubMed
O32268 (AlphaFold)
Expression and Regulation
Operons
Genes
tuaA/2-tuaA/1-tuaB-tuaC-tuaD-tuaE-tuaF-tuaG-tuaH
Description
PubMed
Regulation
expressed during sporulation in the forespore (SigF) PubMed
Regulatory mechanism
PhoP: activation, PubMed, in phoP regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigF: sigma factor, PubMed, in sigF regulon
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tuaA/2→tuaH

2025-04-03 08:59:52

Jstuelk

117

761c7ee893d8412e202f5ec96ccf574895435d9d

E7C38AD5E6CAA14FB6A6EA9BA986E36B3BBE7E1D

Biological materials
Mutant
BKE35550 (tuaG::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGATCACATCTCCATCGT,  downstream forward: _UP4_TAGCTGCAAACAGAGAGAAA
BKK35550 (tuaG::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGATCACATCTCCATCGT,  downstream forward: _UP4_TAGCTGCAAACAGAGAGAAA
References
Sobhanifar S, Worrall LJ, King DT, Wasney GA, Baumann L, Gale RT, Nosella M, Brown ED, Withers SG, Strynadka NC Structure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid β-glycosyltransferase Involved in Methicillin Resistance. PLoS pathogens. 2016 Dec; 12(12):e1006067. doi:10.1371/journal.ppat.1006067. PMID:27973583
Wang ST, Setlow B, Conlon EM, Lyon JL, Imamura D, Sato T, Setlow P, Losick R, Eichenberger P The forespore line of gene expression in Bacillus subtilis. Journal of molecular biology. 2006 Apr 21; 358(1):16-37. . PMID:16497325
Lahooti M, Harwood CR Transcriptional analysis of the Bacillus subtilis teichuronic acid operon. Microbiology (Reading, England). 1999 Dec; 145 ( Pt 12):3409-17. . PMID:10627039
Soldo B, Lazarevic V, Pagni M, Karamata D Teichuronic acid operon of Bacillus subtilis 168. Molecular microbiology. 1999 Feb; 31(3):795-805. . PMID:10048024
Liu W, Hulett FM Comparison of PhoP binding to the tuaA promoter with PhoP binding to other Pho-regulon promoters establishes a Bacillus subtilis Pho core binding site. Microbiology (Reading, England). 1998 May; 144 ( Pt 5):1443-50. . PMID:9611818

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Page visits: 4738

Time of last update: 2025-04-07 11:09:54

Author of last update: Melvin.boenninger