cotQ

cotQ
168

outer spore coat protein

Locus
BSU_34520
Molecular weight
49.92 kDa
Isoelectric point
6.1
Protein length
447 aaSequenceBlast
Gene length
1344 bpSequenceBlast
Function
protection of the spore
Product
spore coat protein
Essential
no
Synonyms
cotQ, yvdP
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0277 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,542,943 → 3,544,286
The protein
Protein family
oxygen-dependent FAD-linked oxidoreductase family (with YitY and YgaK, according to UniProt)
Domains
FAD-binding PCMH-type domain (aa 29-201) (according to UniProt)
Cofactors
FAD (according to UniProt)
Structure
3W8W (PDB) (EncM from Streptomyces maritimus, 32% identity) PubMed
O06997 (AlphaFold)
Paralogous protein(s)
YgaK, (40%)
Localization
outer spore coat, localization depends on CotE  PubMed
Expression and Regulation
Operons
Genes
cotQ
Description
PubMed
Regulation
expressed late during sporulation (SigG, SigK, GerE) PubMed
Regulatory mechanism
GerE: activation, PubMed, in gerE regulon
Sigma factors
SigK: sigma factor, PubMed, in sigK regulon
SigG: sigma factor, PubMed, in sigG regulon
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cotQ

2025-04-03 12:56:02

ghost

121

6612c78f29fe73761013dd98636ad0989247c30c

E8FB92E3109446E08BBE85E8756F3DE2CA1C0CC4

Biological materials
Mutant
MGNA-B620 (yvdP::erm), available at the NBRP B. subtilis, Japan
BKE34520 (ΔcotQ::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATATTATTTCACTCCCA,  downstream forward: _UP4_TAAAGTTTATTAAAGACAGA
BKK34520 (ΔcotQ::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATATTATTTCACTCCCA,  downstream forward: _UP4_TAAAGTTTATTAAAGACAGA
References
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Page visits: 5284

Time of last update: 2025-04-14 06:53:43

Author of last update: Melvin.boenninger