CsoR

• Description: transcription repressor of copZ-copA
  
  

Gene name	csoR
Synonyms	yvgZ
Essential	no
Product	transcription repressor
Function	control of copper homeostasis
Gene expression levels in SubtiExpress: csoR
Metabolic function and regulation of this protein in SubtiPathways: metal ion homeostasis
MW, pI	11 kDa, 7.299
Gene length, protein length	303 bp, 101 aa
Immediate neighbours	copZ, yvaA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), transcription factors and their control, resistance against toxic metals

The CsoR regulon:

• copZ-copA, yotD

The gene

Basic information

• Locus tag: BSU33520

Database entries

• BsubCyc: BSU33520

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: Cu(I) ions cause release of CsoR from its operator sites

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU33520

• Structure:

• UniProt: O32222

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: csoR PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

Mohamed Marahiel, Marburg University, Germany homepage

References

Reviews

Corinna Rademacher, Bernd Masepohl
Copper-responsive gene regulation in bacteria.
Microbiology (Reading): 2012, 158(Pt 10);2451-2464
[PubMed:22918892] [WorldCat.org] [DOI] (I p)