dnaE

dnaE
168

lagging strand DNA polymerase III (alpha subunit), part of the replisome

Locus
BSU_29230
Molecular weight
125.14 kDa
Isoelectric point
6.02
Protein length
1115 aaSequenceBlast
Gene length
3348 bpSequenceBlast
Function
DNA replication(lagging strand)
Product
lagging strand DNA polymerase III (alpha subunit)
Essential
yes
E.C.
2.7.7.7
Synonyms
dnaE
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0587 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,991,269  2,994,616
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
2'-deoxyribonucleoside 5'-triphosphate + DNA(n) --> diphosphate + DNA(n+1) (according to UniProt)
required for bacteriophage SPP1 replication PubMed
Protein family
DNA polymerase type-C family (with YorL and PolC, according to UniProt)
Structure
3E0D (PDB) (from Thermus aquaticus, 39% identity) PubMed
O34623 (AlphaFold)
Localization
forms foci, the foci dissappear after the formation of DNA mismatches in a MutS-dependent manner or after DNA replication arrest PubMed
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
dnaE-ytsJ
Description
PubMed
Regulation
induced by DNA damage (LexA) PubMed
Regulatory mechanism
LexA: repression, PubMed, in lexA regulon
Open in new tab

dnaE→ytsJ

2025-04-19 23:25:52

Jstuelk

180

5807e5e50bd25f38dbc805171d3f14f5354cd973

F93681166D0A46D0BAA5D0678231F87A3D3BB25B

References
Reviews
Loading
Original Publications
Loading

65B5EA4DBDF5B260DED754B8A7B226AA88F17B55

Page visits: 5835

Time of last update: 2025-04-25 08:42:00

Author of last update: Jstuelk