mltG

mltG
168

lytic tranglycosylases, potential terminase for peptidoglycan polymerization

Locus
BSU_27370
Molecular weight
40.34 kDa
Isoelectric point
9.65
Protein length
360 aaSequenceBlast
Gene length
1083 bpSequenceBlast
Function
determination of peptidoglycan chain length
Product
lytic tranglycosylases
Essential
no
Synonyms
yrrL
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1559 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,795,887  2,796,969
The protein
Catalyzed reaction/ biological activity
endolytic transglycosylase PubMed
competes with the transpeptidase activity of class A PBPs PubMed
produces glycan strands with a length of 7 disaccharide units from cleavage in the nascent strands PubMed
cleaves the nascent strands to produce short glycan strands that are used in the cell for a yet unknown process PubMed
Protein family
transglycosylase MltG family (single member, according to UniProt)
Structure
4IIW (PDB) (from L. monocytogenes, 51% identity)
O34758 (AlphaFold)
Expression and Regulation
Operons
Genes
mltG
Description
PubMed
Regulation
repressed under conditions that trigger sporulation (Spo0A) PubMed
Regulatory mechanism
Spo0A: repression, PubMed, in spo0A regulon
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mltG

2025-04-11 08:15:27

ghost

94

1b1d0dc6a77ce8a2642d0397bc4069a32ef4d4f8

63E816D1063A564D4B75A6A9FFE47C46D1907A6A

Biological materials
Mutant
MGNA-A854 (yrrL::erm), available at the NBRP B. subtilis, Japan
BKE27370 (mltG::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTAGGTCTCCTCCCATCA,  downstream forward: _UP4_TAAAAGGAGAGCAAAAAGCT
BKK27370 (mltG::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTAGGTCTCCTCCCATCA,  downstream forward: _UP4_TAAAAGGAGAGCAAAAAGCT
References
Reviews
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Original Publications
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41BCD18A1C2D0C69D4445BE14D4617CC61FB23BF

Page visits: 2695

Time of last update: 2025-04-13 21:41:23

Author of last update: Jstuelk