xerD

xerD
168

site-specific integrase/recombinase, partitioning of the terminus region after replication, terminus-specific unloader of translocating SMC complexes

Locus
BSU_23510
Molecular weight
33.84 kDa
Isoelectric point
10
Protein length
296 aaSequenceBlast
Gene length
891 bpSequenceBlast
Function
chromosome partitioning, unloading of SMC complexes
Product
site-specific integrase/recombinase
Essential
no
Synonyms
ripX, ykqM
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG4974 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,448,591  2,449,481
The protein
Catalyzed reaction/ biological activity
resolution of chromosome dimers by site specific recombination at the dif site (located close to the terminus region on the chromosome)
functions as a site-specific unloader of translocating Smc-ScpA-ScpB complexes at the replication terminus PubMed
Protein family
phage integrase family (according to UniProt)
Structure
1A0P (PDB) (from E. coli, 44% identity, complex with CodV) PubMed
P46352 (AlphaFold)
Paralogous protein(s)
CodV
Localization
cytoplasm (according to Swiss-Prot)
assembles on the chromosome at the dif site throughout the cell cycle PubMed
Biological materials
Mutant
MGNA-C414 (xerD::erm), available at the NBRP B. subtilis, Japan
1A793 ( xerD::spec), PubMed, available at BGSC
1A796 (xerD::spec), PubMed, available at BGSC
BKE23510 (xerD::erm trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CTTTATTTGATCTTTCACTC,  downstream forward: _UP4_TAGCCGCAGGTGGCTGCGGC
BKK23510 (xerD::kan trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CTTTATTTGATCTTTCACTC,  downstream forward: _UP4_TAGCCGCAGGTGGCTGCGGC
References
Reviews
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Original Publications
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Time of last update: 2025-04-10 18:28:44

Author of last update: Jstuelk