cca
168

tRNA nucleotidyltransferase, maturation of the single-copy tRNACys, which lacks an encoded CCA 3 end

Locus

BSU_22450

Molecular weight

45.29 kDa

Isoelectric point

8.04

Protein length

397 aaSequenceBlast

Gene length

1194 bpSequenceBlast

Function

tRNA modification

Product

tRNA nucleotidyltransferase

Essential

yes

E.C.

2.7.7.25

Synonyms

cca, papS, ypjI

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0617 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

2,355,880 2,357,073

Phenotypes of a mutant

essential PubMed

The protein

Catalyzed reaction/ biological activity

tRNA precursor + ATP + 2 CTP --> tRNA with 3' CCA end + 3 diphosphate (according to UniProt)

Protein family

tRNA nucleotidyltransferase/poly(A) polymerase family (single member, according to UniProt)

the protein is similar to the E. coli poly(A) polymerase

Structure

1MIV (PDB) (Geobacillus stearothermophilus 44% identity)

P42977 (AlphaFold)

Expression and Regulation

Operons

Genes

ypjD-dapB-mgsA-bshB1-bshA-cca-birA

Description

PubMed

Regulation

induced by diamide stess (thiol depletion) (Spx) PubMed

Regulatory mechanism

Spx: activation, PubMed, in spx regulon

Sigma factors

SigA: sigma factor, PubMed, in sigA regulon

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References

Reviews

Original Publications

Operon and expression

Page visits: 2568

Time of last update: 2025-04-16 21:52:29

Author of last update: Melvin.boenninger

cca 168

cca
168