kdgA

kdgA
168

2-dehydro-3-deoxy-phosphogluconate aldolase

Locus
BSU_22100
Molecular weight
20.72 kDa
Isoelectric point
5.27
Protein length
196 aaSequenceBlast
Gene length
591 bpSequenceBlast
Function
utilization of galacturonic acid
Product
2-dehydro-3-deoxy-phosphogluconate aldolase
Essential
no
E.C.
4.1.3.16
Synonyms
kdgA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0800 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,323,009  2,323,599
The protein
Catalyzed reaction/ biological activity
4-hydroxy-2-oxoglutarate --> glyoxylate + pyruvate (according to UniProt)
2-dehydro-3-deoxy-6-phospho-D-gluconate --> D-glyceraldehyde 3-phosphate + pyruvate (according to UniProt)
Protein family
KHG/KDPG aldolase family (single member, according to UniProt)
Structure
1VLW (PDB) (from Thermotoga maritima, 41% identity)
P50846 (AlphaFold)
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
kdgR-kdgK-kdgA-kdgT
Description
PubMed
Regulation
induced by galacturonate (KdgR) PubMed
Regulatory mechanism
KdgR: repression, PubMed, in kdgR regulon
CcpA: repression, PubMed, in ccpA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

kdgR→kdgT

2025-03-27 16:20:43

Jstuelk

99

a5bed599599ed10a0553e473cf3c537c32010d6c

3F117D89C62E073C1B4EEA2460C1BBFC9A05A5A3

Biological materials
Mutant
BKE22100 (kdgA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GTTTTCAACGACTTTGGACT,  downstream forward: _UP4_TAAGTGGAATTGTTTTTTCA
BKK22100 (kdgA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GTTTTCAACGACTTTGGACT,  downstream forward: _UP4_TAAGTGGAATTGTTTTTTCA
References
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826BFCE6ED2113BB0510E798C6CDB05C4665E0E2

Page visits: 2067

Time of last update: 2025-04-10 14:29:52

Author of last update: Melvin.boenninger