uxuA

uxuA
168

D-mannonate hydrolyase

Locus
BSU_12340
Molecular weight
40.87 kDa
Isoelectric point
4.92
Protein length
359 aaSequenceBlast
Gene length
1080 bpSequenceBlast
Function
hexuronate utilization
Product
D-mannonate hydrolyase
Essential
no
E.C.
4.2.1.8
Synonyms
uxuA, yjmE
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1312 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,305,486  1,306,565
The protein
Catalyzed reaction/ biological activity
D-mannonate --> 2-dehydro-3-deoxy-D-gluconate + H2O (according to UniProt)
Protein family
mannonate dehydratase family (single member, according to UniProt)
Structure
1TZ9 (PDB) (from Enterococcus faecalis, 44% identity)
O34346 (AlphaFold)
Expression and Regulation
Operons
Genes
yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA
Description
PubMed
Regulation
induced by galacturonate (ExuR) PubMed
Regulatory mechanism
ExuR: repression, in the absence of inducer, in exuR regulon
CcpA: repression, PubMed PubMed, in ccpA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigE: sigma factor, PubMed, in sigE regulon
Open in new tab

yjmC→uxaA

2025-04-08 12:07:13

ghost

93

e9b60dda83535baf9252c89c7130d2fdeb844e6f

417675688A3DB0A933113CA632D3321516D969A2

Genes
uxaC-yjmB-yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA
Description
PubMed
Regulation
induced by galacturonate (ExuR) PubMed
Regulatory mechanism
ExuR: repression, in the absence of inducer, in exuR regulon
CcpA: repression, PubMed PubMed, in ccpA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

uxaC→uxaA

2025-04-03 12:22:40

ghost

96

0325999ea185bfaaf2dea87e1701479c52256033

A15F6E93B04DC8C4B59B7976DAC34CE9AC0B8E51

Biological materials
Mutant
MGNA-A369 (yjmE::erm), available at the NBRP B. subtilis, Japan
BKE12340 (uxuA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCTCGCACCTCCGGATT,  downstream forward: _UP4_ATGGCAAAAAAAGAGGTGGG
BKK12340 (uxuA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCTCGCACCTCCGGATT,  downstream forward: _UP4_ATGGCAAAAAAAGAGGTGGG
References
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A0A6D36BEC397345A1D17E6A7C34E1F612FD46C7

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Time of last update: 2025-04-14 05:30:25

Author of last update: Melvin.boenninger