yjmC
168

similar to ureidoglycolate dehydrogenase, may be involved in galacturonate utilization

Locus

BSU_12320

Molecular weight

36.32 kDa

Isoelectric point

5.67

Protein length

337 aaSequenceBlast

Gene length

1014 bpSequenceBlast

Function

unknown

Product

unknown

Essential

Synonyms

yjmC

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2055 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

1,303,423 1,304,436

The protein

Protein family

LDH2/MDH2 oxidoreductase family (single member, according to UniProt)

Structure

4H8A (PDB) (ureidoglycolate dehydrogenase from E. coli, 41% identity) PubMed

O34736 (AlphaFold)

Localization

cytoplasm (according to Swiss-Prot)

Additional information

The gene is annotated in KEGG as an ortholog of malate dehydrogenase EC 1.1.1.37. but it is marked as uncharacterized oxidoreductase (EC 1.1.1.-) in Swiss-Prot. In MetaCyc it is marked as similar to malate dehydrogenase. As the paper by Mekjian et al. PubMed suggests this gene is more likely to be involved in the glucuronate pathway (for which EC 1.1.1.37 is not a member), no literature/experimental evidence supporting the annotation is available. PubMed

Expression and Regulation

Operons

Genes

yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA

Description

PubMed

Regulation

induced by galacturonate (ExuR) PubMed

Regulatory mechanism

ExuR: repression, in the absence of inducer, in exuR regulon

CcpA: repression, PubMed PubMed, in ccpA regulon

Sigma factors