yhcA

yhcA
168

c-di-AMP exporter

Locus
BSU_09010
Molecular weight
58.17 kDa
Isoelectric point
9.49
Protein length
532 aaSequenceBlast
Gene length
1599 bpSequenceBlast
Function
secretion of cyclic di-AMP
Product
c-di-AMP exporter
Essential
no
Synonyms
yhcA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms, belongs to COG2814 (Galperin et al., 2021)

Gene
Coordinates
977,775  979,373
The protein
Catalyzed reaction/ biological activity
secretion of cyclic di-AMP PubMed
Protein family
major facilitator superfamily (according to UniProt)
EmrB family (according to UniProt)
Structure
6E8J (PDB) (from Hyphomonas neptunium, corresponds to aa 93 ... 204, 28% identity)
P54585 (AlphaFold)
Paralogous protein(s)
YcnB, LmrB
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
yhbI-yhbJ-yhcA-yhcB-yhcC
Description
PubMed
Additional information
the mRNA is substantially stabilized upon depletion of RNase Y (the half-life of the mRNA increases from 4 to 41 min) PubMed
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yhbI→yhcC

2025-03-17 19:03:07

Jstuelk

67

65b8eed6f6195e33988a759b72502a718556f155

51EDE59EF3FA1E0885DE1370B2F6E6D734862A76

Biological materials
Mutant
MGNA-B471 (yhcA::erm), available at the NBRP B. subtilis, Japan
GP1704 (''yhcA::ermC'', without terminator), available in Jörg Stülke's lab
BKE09010 (yhcA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTAAGACAACCTCCTTT,  downstream forward: _UP4_TAATCTGTACAGGGAGGTTT
BKK09010 (yhcA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTAAGACAACCTCCTTT,  downstream forward: _UP4_TAATCTGTACAGGGAGGTTT
References
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93159DC7D5C42CFA54F66F232D73F38957243AB7

Page visits: 2898

Time of last update: 2025-04-04 03:27:44

Author of last update: Jstuelk