lnrM

lnrM
168

similar to ABC transporter (membrane protein), involved in resistance to linearmycin

Locus
BSU_08320
Molecular weight
42.95 kDa
Isoelectric point
9.62
Protein length
396 aaSequenceBlast
Gene length
1191 bpSequenceBlast
Function
resistance to linearmycin
Product
ABC transporter (membrane protein)
Essential
no
Synonyms
yfiM
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0842 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
906,764  907,954
Phenotypes of a mutant
overexpression of lnrM and lnrN stimulates biofilm formation PubMed
The protein
Protein family
ABC-2 integral membrane protein family (according to UniProt)
Domains
ABC transmembrane type-2 domain (aa 161-396) (according to UniProt)
Structure
P94441 (AlphaFold)
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
lnrL-lnrM-lnrN
Description
PubMed
Regulation
expression during spore germination is increased under conditions of osmotic stress PubMed
induced in the presence of linearmycin and other polyenes (LnrK) PubMed
Regulatory mechanism
LnrK: activation, PubMed, in lnrK regulon
Sigma factors
SigF: sigma factor, in sigF regulon
SigG: sigma factor, in sigG regulon
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lnrL→lnrN

2025-03-07 04:44:44

Jstuelk

73

7fa1f47baf646398b2d2b81a08036e691ef5d550

3B045C04B4C45662F4875ADEB7A4D524530CAE31

Biological materials
Mutant
MGNA-C302 (yfiM::erm), available at the NBRP B. subtilis, Japan
BKE08320 (lnrM::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GCTTTTTTTCATTGCCGTCC,  downstream forward: _UP4_CATACAAGATAAGGAGGTAC
BKK08320 (lnrM::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GCTTTTTTTCATTGCCGTCC,  downstream forward: _UP4_CATACAAGATAAGGAGGTAC
References
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07858BFC72EB0B6AF615C8D4C8BCC162D8C3E7D2

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Time of last update: 2025-04-10 18:48:36

Author of last update: Jstuelk