gmuB

gmuB
168

glucomannan-specific permease of the phosphotransferase system, EIIB of the PTS

Locus
BSU_05810
Molecular weight
11.30 kDa
Isoelectric point
4.72
Protein length
103 aaSequenceBlast
Gene length
312 bpSequenceBlast
Function
glucomannan uptake and phosphorylation
Product
glucomannan-specific lichenan-specific PTS, EIIB component
Essential
no
Synonyms
gmuB, ydhM
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1440 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
626,622  626,933
The protein
Catalyzed reaction/ biological activity
D-cellobiose + Nπ-phospho-L-histidyl-[protein] --> 6-phospho-β-D-glucosyl-(1→4)-D-glucose + L-histidyl-[protein] (according to UniProt)
Protein family
PTS permease, lactose family PubMed
Domains
PTS EIIB domain type-3 (aa 1-103) (according to UniProt)
Structure
4MGE (PDB) (from B. anthracis, 46% identity)
O05505 (AlphaFold)
Paralogous protein(s)
LicB
Expression and Regulation
Operons
Genes
gmuB-gmuA-gmuC-gmuD-gmuR-gmuE-gmuF-gmuG
Description
PubMed
Regulation
induced by cellobiose (GmuR) PubMed
Regulatory mechanism
GmuR: repression, PubMed, in gmuR regulon
CcpA: repression, PubMed, in ccpA regulon
AbrB: activation, PubMed, in abrB regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

gmuB→gmuG

2025-03-16 15:57:23

Jstuelk

109

1716709ba10a9af523abc0d89eb44ea784dd12d9

42FBC6CD7712CC913DB98C4B417CB4A13C8FAE20

Biological materials
Mutant
MGNA-C188 (ydhM::erm), available at the NBRP B. subtilis, Japan
BKE05810 (gmuB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAACTGCTATCCCCCCTGTT,  downstream forward: _UP4_TTGTCCTTAATGGTGAATCA
BKK05810 (gmuB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAACTGCTATCCCCCCTGTT,  downstream forward: _UP4_TTGTCCTTAATGGTGAATCA
References
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Page visits: 6346

Time of last update: 2025-04-07 07:11:04

Author of last update: Melvin.boenninger