natR

natR
168

two-component response regulator, regulation of the natA-natB operon

Locus
BSU_02740
Molecular weight
26.82 kDa
Isoelectric point
6.61
Protein length
233 aaSequenceBlast
Gene length
702 bpSequenceBlast
Function
regulation of the natA-natB operon
Product
two-component response regulator
Essential
no
Synonyms
natR, yccH
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3279 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
295,584 → 296,285
The protein
Protein family
OmpR family of two-component response regulators
Domains
Response regulatory domain (aa 3-117) (according to UniProt)
HTH LytTR-type domain (aa 129-233) (according to UniProt)
Structure
5HEV (PDB) (from Enterococcus faecium, corresponds to aa 1 ... 172, 22.3% identity) PubMed
P70955 (AlphaFold)
Modification
phosphorylated by NatK on an Asp residue
Effectors of protein activity
phosphorylation likely affects DNA-binding activity
Localization
cytoplasm (according to UniProt)
Expression and Regulation
Operons
Genes
natR-natK
Description
PubMed
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natR→natK

2025-04-07 06:19:16

Jstuelk

107

6033418d44d4ee934be10c40c9057897d0b92659

ACC0CCF7E3D9FD26556A01A19C0236CC1543064C

Biological materials
Mutant
MGNA-C043 (yccH::erm), available at the NBRP B. subtilis, Japan
BKE02740 (ΔnatR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTATCATTCCCCTAGTTA,  downstream forward: _UP4_TACTATTTTTGAGGAGTTTA
BKK02740 (ΔnatR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTATCATTCCCCTAGTTA,  downstream forward: _UP4_TACTATTTTTGAGGAGTTTA
References
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Page visits: 3400

Time of last update: 2025-04-11 04:36:44

Author of last update: Christoph.elfmann