lmrB

lmrB
168

lincomycin-resistance protein (multidrug resistance pump)

Locus
BSU_02670
Molecular weight
51.54 kDa
Isoelectric point
9.7
Protein length
479 aaSequenceBlast
Gene length
1440 bpSequenceBlast
Function
resistance to lincomycin
Product
lincomycin-resistance protein
Essential
no
Synonyms
lmrB, yccA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2814 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
288,653  290,092
The protein
Protein family
major facilitator superfamily (according to UniProt)
EmrB family (according to UniProt)
Structure
O35018 (AlphaFold)
Paralogous protein(s)
YhcA, YcnB
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
lmrA-lmrB
Description
PubMed
Regulation
induced by flavonoids such as quercetin (LmrA)PubMed
Regulatory mechanism
LmrA: repression, PubMed, in lmrA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Additional information
the mRNA is substantially stabilized upon depletion of RNase Y PubMed
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lmrA→lmrB

2025-04-06 20:43:13

ghost

114

be7795d98f26be96a984dc95802c21f2dcb1e545

FCA0758D41C878E1059BF369D1C30C97AACB6B0C

Biological materials
Mutant
GP1701 (''lmrB::aphA3''), available in Jörg Stülke's lab
GP1703 (''lmrB::aphA3 ycnB::spc''), available in Jörg Stülke's lab
BKE02670 (lmrB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTCCCCTCTCTATCAAC,  downstream forward: _UP4_TAATATGAAAAGCCCCTGAC
BKK02670 (lmrB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTCCCCTCTCTATCAAC,  downstream forward: _UP4_TAATATGAAAAGCCCCTGAC
References
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23483430AE0381406EF2349A18CFAE1F14F9B180

Page visits: 5523

Time of last update: 2025-04-05 21:39:14

Author of last update: Melvin.boenninger