pabC

pabC
168

aminodeoxychorismate lyase

Locus
BSU_00760
Molecular weight
33.36 kDa
Isoelectric point
6.12
Protein length
293 aaSequenceBlast
Gene length
882 bpSequenceBlast
Function
biosynthesis of folate
Product
aminodeoxychorismate lyase
Essential
no
E.C.
4.1.3.38
Synonyms
pabC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms, belongs to COG0115 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
84,874  85,755
The protein
Catalyzed reaction/ biological activity
4-amino-4-deoxychorismate --> 4-aminobenzoate + pyruvate (according to UniProt)
Protein family
Class-IV pyridoxal-phosphate-dependent aminotransferase family (according to UniProt)
Cofactors
PLP
Structure
5MR0 (PDB) (from Archaeoglobus fulgidus, 33.7% identity) PubMed
P28821 (AlphaFold)
Localization
cytoplasm (according to UniProt)
Expression and Regulation
Operons
Genes
pabB-pabA-pabC-sul-folB-folK-yazB-dusB1-lysS
Description
PubMed
Regulation
translation repressed by tryptophan (MtrB) PubMed
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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pabB→lysS

2025-04-04 11:44:49

Jstuelk

121

8c465dd3eec1aaa32d5e91206834f9bb99ef474a

7B9041CE94396BF42D285F7C0EDD3A2544761EEE

Additional information
the pabA-pabC part of the mRNA is substantially stabilized upon depletion of RNase Y PubMed
Biological materials
Mutant
BKE00760 (pabC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_ATACCGGCCGTTCACATATA,  downstream forward: _UP4_ATTCATGAAAAGGGAGGAAG
BKK00760 (pabC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_ATACCGGCCGTTCACATATA,  downstream forward: _UP4_ATTCATGAAAAGGGAGGAAG
References
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Time of last update: 2025-04-05 16:56:19

Author of last update: Jstuelk