Difference between revisions of "PrsA"
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| − | * '''Description:''' post-translocational folding of exported proteins (post-translocation molecular chaperone) <br/><br/> | + | * '''Description:''' lipoprotein, post-translocational folding of exported proteins (post-translocation molecular chaperone) <br/><br/> |
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' catalyses the post-translocational folding of exported proteins {{PubMed|20487272}}, required for folding of [[penicillin-binding proteins]] ([[PbpA]], [[PbpB]], [[PbpC]], [[PbpD]]) {{PubMed|20487272}} | + | * '''Catalyzed reaction/ biological activity:''' |
| + | ** catalyses the post-translocational folding of exported proteins {{PubMed|20487272}}, required for folding of [[penicillin-binding proteins]] ([[PbpA]], [[PbpB]], [[PbpC]], [[PbpD]]) {{PubMed|20487272}} | ||
* '''Protein family:''' PpiC domain (according to Swiss-Prot) | * '''Protein family:''' PpiC domain (according to Swiss-Prot) | ||
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
* '''Modification:''' | * '''Modification:''' | ||
** PrsA is a lipoprotein with a N-acetyl-S-diacyl-glyceryl-cysteine structure {{PubMed|22303020}} | ** PrsA is a lipoprotein with a N-acetyl-S-diacyl-glyceryl-cysteine structure {{PubMed|22303020}} | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=prsA_1070364_1071242_-1 prsA] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=prsA_1070364_1071242_-1 prsA] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' | + | * '''[[Sigma factor]]:''' |
* '''Regulation:''' | * '''Regulation:''' | ||
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* '''Additional information:''' | * '''Additional information:''' | ||
| + | ** [[PrsA]] is subject to degradation by [[WprA]] and other extracellular proteases {{PubMed|24362423}} | ||
=Biological materials = | =Biological materials = | ||
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=References= | =References= | ||
| − | <pubmed>12634326,14976191,11807061,10096076,18763711, 10871614 20487272 22303020</pubmed> | + | <pubmed>12634326,14976191,11807061,10096076,18763711, 10871614 20487272 22303020 24362423 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 16:28, 16 January 2014
- Description: lipoprotein, post-translocational folding of exported proteins (post-translocation molecular chaperone)
| Gene name | prsA |
| Synonyms | |
| Essential | yes PubMed |
| Product | post-translocation molecular chaperone |
| Function | protein folding |
| Gene expression levels in SubtiExpress: prsA | |
| Interactions involving this protein in SubtInteract: PrsA | |
| Metabolic function and regulation of this protein in SubtiPathways: Protein secretion | |
| MW, pI | 32 kDa, 9.122 |
| Gene length, protein length | 876 bp, 292 aa |
| Immediate neighbours | yhaL, sscA |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
protein secretion, essential genes, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU09950
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: PpiC domain (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- PrsA is a lipoprotein with a N-acetyl-S-diacyl-glyceryl-cysteine structure PubMed
- Effectors of protein activity:
- Interactions:
- dimeric or oligomeric protein PubMed
Database entries
- Structure: 1ZK6
- UniProt: P24327
- KEGG entry: [2]
- E.C. number: 5.2.1.8
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
