Difference between revisions of "YpbH"

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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU22970 ypbH]
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU22970 ypbH]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/YpbH YpbH]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=YpbH YpbH]
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 22 kDa, 4.095   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 22 kDa, 4.095   

Revision as of 08:44, 12 November 2013

  • Description: putative adaptor protein for ClpC-ClpP

Gene name ypbH
Synonyms
Essential no
Product putative adaptor protein
Function unknown
Gene expression levels in SubtiExpress: ypbH
Interactions involving this protein in SubtInteract: YpbH
MW, pI 22 kDa, 4.095
Gene length, protein length 582 bp, 194 aa
Immediate neighbours gudB, ypbG
Gene sequence (+200bp) Protein sequence
Genetic context
YpbH context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YpbH expression.png















Categories containing this gene/protein

proteolysis

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU22970

Phenotypes of a mutant

deletion reduces sporulation to 20%, overexpression abolishes sporulation PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s): MecA

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
    • low expression, enhanced in stat phase in LB or competence but not in sporulation medium PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant: GP812 (spc), GP814 (spc) both available in the Stülke lab
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Aurelia Battesti, Susan Gottesman
Roles of adaptor proteins in regulation of bacterial proteolysis.
Curr Opin Microbiol: 2013, 16(2);140-7
[PubMed:23375660] [WorldCat.org] [DOI] (I p)

Janine Kirstein, Noël Molière, David A Dougan, Kürşad Turgay
Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases.
Nat Rev Microbiol: 2009, 7(8);589-99
[PubMed:19609260] [WorldCat.org] [DOI] (I p)

Original Publications