Difference between revisions of "Metabolism of signalling nucleotides"
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===c-di-GMP degradation (presence of an EAL domain)=== | ===c-di-GMP degradation (presence of an EAL domain)=== | ||
| − | * [[ | + | * [[DgcW]] |
* [[YkuI]] | * [[YkuI]] | ||
| − | * [[ | + | * [[PdeH]] |
=== c-di-GMP synthesis/ based on similarity (presence of a GGDEF domain)=== | === c-di-GMP synthesis/ based on similarity (presence of a GGDEF domain)=== | ||
* [[GdpP]] | * [[GdpP]] | ||
* [[YdaK]] | * [[YdaK]] | ||
| − | * [[ | + | * [[DgcK]] |
| − | * [[ | + | * [[DgcW]] |
| − | * [[ | + | * [[DgcP]] (this enzyme lacks important residues) |
=== Targets of signalling nucleotides === | === Targets of signalling nucleotides === | ||
| Line 52: | Line 52: | ||
* c-di-GMP targets | * c-di-GMP targets | ||
| − | ** [[ | + | ** [[DgrA]] (contains a PilZ domain) |
* potential c-di-AMP targets | * potential c-di-AMP targets | ||
| − | ** [[KtrA]] (binds c-di-AMP ''in vivo'') {{PubMed|23671116}} | + | ** [[KtrA]] (binds c-di-AMP ''in vivo'') {{PubMed|23671116}} |
==Important original publications== | ==Important original publications== | ||
Revision as of 10:33, 10 August 2013
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Contents
Genes in this functional category
ppGpp synthesis and degradation
c-di-AMP synthesis
Control of c-di-AMP synthesis
Note that c-di-AMP is essential for the growth of B. subtilis, but accumulation of the nucleotide is detrimental as well PubMed
c-di-AMP degradation
c-di-GMP degradation (presence of an EAL domain)
c-di-GMP synthesis/ based on similarity (presence of a GGDEF domain)
Targets of signalling nucleotides
- c-di-GMP targets
- DgrA (contains a PilZ domain)
Important original publications
Xiaohui Gao, Sampriti Mukherjee, Paige M Matthews, Loubna A Hammad, Daniel B Kearns, Charles E Dann
Functional characterization of core components of the Bacillus subtilis cyclic-di-GMP signaling pathway.
J Bacteriol: 2013, 195(21);4782-92
[PubMed:23893111]
[WorldCat.org]
[DOI]
(I p)
Rebecca M Corrigan, Ivan Campeotto, Tharshika Jeganathan, Kevin G Roelofs, Vincent T Lee, Angelika Gründling
Systematic identification of conserved bacterial c-di-AMP receptor proteins.
Proc Natl Acad Sci U S A: 2013, 110(22);9084-9
[PubMed:23671116]
[WorldCat.org]
[DOI]
(I p)
Felix M P Mehne, Katrin Gunka, Hinnerk Eilers, Christina Herzberg, Volkhard Kaever, Jörg Stülke
Cyclic di-AMP homeostasis in bacillus subtilis: both lack and high level accumulation of the nucleotide are detrimental for cell growth.
J Biol Chem: 2013, 288(3);2004-17
[PubMed:23192352]
[WorldCat.org]
[DOI]
(I p)
Allison Kriel, Alycia N Bittner, Sok Ho Kim, Kuanqing Liu, Ashley K Tehranchi, Winnie Y Zou, Samantha Rendon, Rui Chen, Benjamin P Tu, Jue D Wang
Direct regulation of GTP homeostasis by (p)ppGpp: a critical component of viability and stress resistance.
Mol Cell: 2012, 48(2);231-41
[PubMed:22981860]
[WorldCat.org]
[DOI]
(I p)
Yaara Oppenheimer-Shaanan, Ezequiel Wexselblatt, Jehoshua Katzhendler, Eylon Yavin, Sigal Ben-Yehuda
c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis.
EMBO Rep: 2011, 12(6);594-601
[PubMed:21566650]
[WorldCat.org]
[DOI]
(I p)
Important reviews
