Difference between revisions of "Main Page"
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<big>'''Paper of the month: August 2013'''</big> | <big>'''Paper of the month: August 2013'''</big> | ||
* In cells, the concentration of ribonucleotides by far exceeds that of deoxyribonucleotides. This poses problems since the DNA polymerase incorporates one rNTP every 2.3 kb during [[DNA replication|chromosome replication]]. Now, [http://www.ncbi.nlm.nih.gov/pubmed/23882084 Yao et al.] investigated how these misincorporations are repaired. The demonstrate that this repair is initiated by [[rnhB|RNase HII]] that nicks DNA at single rNMP residues to initiate replacement with dNMP. | * In cells, the concentration of ribonucleotides by far exceeds that of deoxyribonucleotides. This poses problems since the DNA polymerase incorporates one rNTP every 2.3 kb during [[DNA replication|chromosome replication]]. Now, [http://www.ncbi.nlm.nih.gov/pubmed/23882084 Yao et al.] investigated how these misincorporations are repaired. The demonstrate that this repair is initiated by [[rnhB|RNase HII]] that nicks DNA at single rNMP residues to initiate replacement with dNMP. | ||
| − | * '''Relevant ''Subti''Wiki pages:''' [[DNA replication]], [[DNA repair/recombination|DNA repair]], ''[[rnhB]]'', ''[[rnhC]]'', ''[[mutS]]'', ''[[mutL]]'' | + | * '''Relevant ''Subti''Wiki pages:''' [[DNA replication]], [[DNA repair/ recombination|DNA repair]], ''[[rnhB]]'', ''[[rnhC]]'', ''[[mutS]]'', ''[[mutL]]'' |
<pubmed> 23882084 </pubmed> | <pubmed> 23882084 </pubmed> | ||
Revision as of 12:54, 1 August 2013
Welcome to SubtiWiki! - Bacillus subtilis annotation the "wiki" way!
Contact: General Microbiology, University of Göttingen, send mail
Upcoming events:
- The 6th European Spores Conference will be held in London from April 9 to April 11, 2014. The meeting will be organized by Simon Cutting and Imrich Barak, website, contact
- The next European BACELL meeting will take place in Bratislava from April 29 to April 30, 2014. The meeting will be organized by Imrich Barak, contact
- Past conferences
New: Subtiwiki is now on Facebook - please give it a +1!
Now online: A description of SubtiWiki, SubtiPathways, and SubtInteract in the 2012 Database issue of Nucleic Acids Research
Ulrike Mäder, Arne G Schmeisky, Lope A Flórez, Jörg Stülke
SubtiWiki--a comprehensive community resource for the model organism Bacillus subtilis.
Nucleic Acids Res: 2012, 40(Database issue);D1278-87
[PubMed:22096228]
[WorldCat.org]
[DOI]
(I p)
Paper of the month: August 2013
- In cells, the concentration of ribonucleotides by far exceeds that of deoxyribonucleotides. This poses problems since the DNA polymerase incorporates one rNTP every 2.3 kb during chromosome replication. Now, Yao et al. investigated how these misincorporations are repaired. The demonstrate that this repair is initiated by RNase HII that nicks DNA at single rNMP residues to initiate replacement with dNMP.
- Relevant SubtiWiki pages: DNA replication, DNA repair, rnhB, rnhC, mutS, mutL
Nina Y Yao, Jeremy W Schroeder, Olga Yurieva, Lyle A Simmons, Mike E O'Donnell
Cost of rNTP/dNTP pool imbalance at the replication fork.
Proc Natl Acad Sci U S A: 2013, 110(32);12942-7
[PubMed:23882084]
[WorldCat.org]
[DOI]
(I p)
New procedure for account creation:
- Due to massive spam attacks, we had to change our policy for the creation of accounts. If you want to create an account, just send me a mail. We will create the account for you as quickly as possible, then you can change your password. This does not affect existing accounts, which remain active.
- Please remember that all members of the Bacillus community are invited to create accounts and to contribute to SubtiWiki!
News in SubtiWiki:
- April 2013: SubtiWiki uses a new, faster Mediawiki platform! The times for page access are significantly reduced. Enjoy!
- March 2013: updated Excel files that map all genes to categories and regulons as well as the general updated identity mapping of all genes were uploaded.
- October 2012: the essential genes have been categorized
- September 2012: 300 mutant strains available at the BGSC were added to the corresponding gene pages
- August 2012: SubtiExpress, the new compagnon of SubtiWiki devoted to gene expression is online! Try it out!
- April 2012: Links for expression data under 104 different conditions (based on Nicolas et al., 2012) have been added to the expression section of the individual gene pages
- April 2011: SubtInteract, a presentation of protein-protein interactions in B. subtilis, is online!
- December 2010: SubtiCellPublisher allows the conversion of CellDesigner diagrams to navigatable presentations in the style of SubtiPathways
- December 2010: all genes are linked to regulons, and the pages of the regulons provide an overview on all genes that are members of this specific regulon.
- December 2010: all genes/proteins are linked to categories, and the pages of the categories provide an overview on all genes/proteins that are members of this specific category.
Publications describing SubtiWiki and SubtiPathways:
Ulrike Mäder, Arne G Schmeisky, Lope A Flórez, Jörg Stülke
SubtiWiki--a comprehensive community resource for the model organism Bacillus subtilis.
Nucleic Acids Res: 2012, 40(Database issue);D1278-87
[PubMed:22096228]
[WorldCat.org]
[DOI]
(I p)
Lope A Flórez, Sebastian F Roppel, Arne G Schmeisky, Christoph R Lammers, Jörg Stülke
A community-curated consensual annotation that is continuously updated: the Bacillus subtilis centred wiki SubtiWiki.
Database (Oxford): 2009, 2009;bap012
[PubMed:20157485]
[WorldCat.org]
[DOI]
(I p)
Christoph R Lammers, Lope A Flórez, Arne G Schmeisky, Sebastian F Roppel, Ulrike Mäder, Leendert Hamoen, Jörg Stülke
Connecting parts with processes: SubtiWiki and SubtiPathways integrate gene and pathway annotation for Bacillus subtilis.
Microbiology (Reading): 2010, 156(Pt 3);849-859
[PubMed:19959575]
[WorldCat.org]
[DOI]
(I p)
