Difference between revisions of "PadR"
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Revision as of 12:48, 16 May 2013
- Description: repressor of yveF-yveG-padC, induction occurs by binding of phenolic acids,stress response
| Gene name | padR |
| Synonyms | yfiO |
| Essential | no |
| Product | transcriptional repressor |
| Function | regulation of the phenolic acid stress response |
| Gene expression levels in SubtiExpress: padR | |
| MW, pI | 21 kDa, 7.231 |
| Gene length, protein length | 546 bp, 182 aa |
| Immediate neighbours | yfiN, lipB |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
transcription factors and their control, resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)
This gene is a member of the following regulons
The PadR regulon:
The gene
Basic information
- Locus tag: BSU08340
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: phenolic acid acts as molecular inducer and releases PadR from the yveF-yveG-padC promoter PubMed
- Localization:
- cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P94443
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: padR (according to DBTBS)
- Sigma factor:
- Regulation: weak constitutive expression
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Thi Kim Chi Nguyen, Ngoc Phuong Tran, Jean-François Cavin
Genetic and biochemical analysis of PadR-padC promoter interactions during the phenolic acid stress response in Bacillus subtilis 168.
J Bacteriol: 2011, 193(16);4180-91
[PubMed:21685295]
[WorldCat.org]
[DOI]
(I p)
Ngoc Phuong Tran, Jerôme Gury, Véronique Dartois, Thi Kim Chi Nguyen, Hélène Seraut, Lise Barthelmebs, Patrick Gervais, Jean-François Cavin
Phenolic acid-mediated regulation of the padC gene, encoding the phenolic acid decarboxylase of Bacillus subtilis.
J Bacteriol: 2008, 190(9);3213-24
[PubMed:18326577]
[WorldCat.org]
[DOI]
(I p)
