PdxS

Gene name	pdxS
Synonyms	yaaD
Essential	no
Product	pyridoxal-5'-phosphate synthase (synthase domain)
Function	pyridoxal-5'-phosphate biosynthesis
Gene expression levels in SubtiExpress: pdxS
Interactions involving this protein in SubtInteract: PdxS
MW, pI	31 kDa, 5.085
Gene length, protein length	882 bp, 294 aa
Immediate neighbours	dacA, pdxT
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors, phosphoproteins

This gene is a member of the following regulons

Spo0A regulon

The gene

Basic information

• Locus tag: BSU00110

Phenotypes of a mutant

auxotrophic for pyridoxal 5'-phosphate PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: pdxS/SNZ family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:
  • phosphorylated on Arg-8 PubMed
  • phosphorylated on STY PubMed, PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • PdxS-PdxT PubMed1 PubMed2

• Localization:

Database entries

• Structure: 2NV2 PdxS-PdxT complex

• UniProt: P37527

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: pdxS-pdxT

• Expression browser: pdxS PubMed

• Sigma factor:

• Regulation: negatively controlled by Spo0A PubMed
  • repressed under conditions that trigger sporulation (Spo0A) PubMed

• Regulatory mechanism:
  • Spo0A: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: