Difference between revisions of "Nth"
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| − | * '''Description:''' endonuclease III <br/><br/> | + | * '''Description:''' endonuclease III, removes abasic sites during base excision repair <br/><br/> |
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * the mutant is sensititive to exposure to H2O2 {{PubMed|21954439}} | ||
=== Database entries === | === Database entries === | ||
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=== Additional information=== | === Additional information=== | ||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| + | ** activity is stimulated by untwisting of the DNA (by [[DnaD]], [[Hbs]], or [[YonN]]) {{PubMed|21954439}} | ||
| − | * '''Interactions:''' | + | * '''[[SubtInteract|Interactions]]:''' |
| − | * '''Localization:''' | + | * '''[[Localization]]:''' |
=== Database entries === | === Database entries === | ||
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=Expression and regulation= | =Expression and regulation= | ||
| − | + | * '''Operon:''' ''[[dnaD]]-[[nth]]'' {{PubMed|21954439}} | |
| − | * '''Operon:''' | ||
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** constitutively expressed {{PubMed|21954439}} | ||
| + | ** expression is transiently increased after treatment with H2O2 {{PubMed|21954439}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| Line 125: | Line 126: | ||
=References= | =References= | ||
| − | <pubmed>12840008</pubmed> | + | <pubmed>12840008 21954439 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 14:22, 30 September 2011
- Description: endonuclease III, removes abasic sites during base excision repair
| Gene name | nth |
| Synonyms | jooB, ypoB |
| Essential | no |
| Product | endonuclease III |
| Function | DNA repair |
| MW, pI | 24 kDa, 9.277 |
| Gene length, protein length | 657 bp, 219 aa |
| Immediate neighbours | ypoC, dnaD |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU22340
Phenotypes of a mutant
- the mutant is sensititive to exposure to H2O2 PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate (according to Swiss-Prot)
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure: 1P59 (complex with DNA, Geobacillus stearothermophilus)
- UniProt: P39788
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
