NupG

• Description: purine nucleoside transporter
  
  

Gene name	nupG
Synonyms	yxjA
Essential	no
Product	purine nucleoside transporter
Function	purine uptake
MW, pI	43 kDa, 7.757
Gene length, protein length	1191 bp, 397 aa
Immediate neighbours	yxjB, yxiT
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

transporters/ other, biosynthesis/ acquisition of nucleotides, membrane proteins

This gene is a member of the following regulons

G-box

The gene

Basic information

• Locus tag: BSU39020

Phenotypes of a mutant

• a nupN nupG double mutant is unable to utilize externally provided guanosine PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: SLC28A transporter family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot), membrane PubMed

Database entries

• Structure:

• UniProt: P42312

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: nupG

• Sigma factor:

• Regulation:
  • expression activated by glucose (4.3 fold) PubMed
  • repressed by hypoxanthine and guanine, PurR-independent, G-boxPubMed

• Regulatory mechanism: G-box: transcriptional termination/ antitermination riboswitch PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: