YxdK

• Description: two-component sensor kinase, regulation of the ABC transporter YxdL-YxdM in response to the cationic antimicrobial peptide, LL-37
  
  

Gene name	yxdK
Synonyms
Essential	no
Product	two-component sensor kinase
Function	resistance against toxic peptides
MW, pI	37 kDa, 6.226
Gene length, protein length	975 bp, 325 aa
Immediate neighbours	yxdL, yxdJ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU39650

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

protein modification, transcription factors and their control, resistance against toxins/ antibiotics, membrane proteins, phosphoproteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of YxdJ

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: two transmembrane segments, C-terminal histidine phosphotransferase domain

• Modification: autophosphorylation on a His residue

• Cofactor(s):

• Effectors of protein activity:

• Interactions: YxdK-YxdJ

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P42422

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: yxdJ-yxdK PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: