Difference between revisions of "SigF"
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
− | * '''Interactions:''' [[SigF]]-[[SpoIIAB]], [[SigF]]-([[RpoB]]-[[RpoC]]) | + | * '''Interactions:''' [[SigF]]-[[Fin]] (probably) {{PubMed|21037003}}, [[SigF]]-[[SpoIIAB]], [[SigF]]-([[RpoB]]-[[RpoC]]) |
* '''Localization:''' cell membrane (according to Swiss-Prot) | * '''Localization:''' cell membrane (according to Swiss-Prot) |
Revision as of 17:02, 3 November 2010
- Description: RNA polymerase forespore-specific (early) sigma factor SigF
Gene name | sigF |
Synonyms | spoIIAC |
Essential | no |
Product | RNA polymerase forespore-specific (early) sigma factor SigF |
Function | transcription of sporulation genes (late mother cell) |
Metabolic function and regulation of this protein in SubtiPathways: Stress | |
MW, pI | 29 kDa, 5.078 |
Gene length, protein length | 765 bp, 255 aa |
Immediate neighbours | spoVAA, spoIIAB |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
The gene
Basic information
- Locus tag: BSU23450
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: sigma-70 factor family (according to Swiss-Prot)
- Paralogous protein(s):
Genes controlled by SigF
dacF-spoIIAA-spoIIAB-sigF, sigG, pbpF, yphA-seaA
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure: 1L0O (complex with SpoIIAB, Geobacillus stearothermophilus)
- UniProt: P07860
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
- Charles Moran, Emory University, NC, USA homepage
Your additional remarks
References
Reviews
Original Publications
Onuma Chumsakul, Hiroki Takahashi, Taku Oshima, Takahiro Hishimoto, Shigehiko Kanaya, Naotake Ogasawara, Shu Ishikawa
Genome-wide binding profiles of the Bacillus subtilis transition state regulator AbrB and its homolog Abh reveals their interactive role in transcriptional regulation.
Nucleic Acids Res: 2011, 39(2);414-28
[PubMed:20817675]
[WorldCat.org]
[DOI]
(I p)
Jin Hwan Do, Masao Nagasaki, Satoru Miyano
The systems approach to the prespore-specific activation of sigma factor SigF in Bacillus subtilis.
Biosystems: 2010, 100(3);178-84
[PubMed:20298743]
[WorldCat.org]
[DOI]
(I p)
Amy H Camp, Richard Losick
A feeding tube model for activation of a cell-specific transcription factor during sporulation in Bacillus subtilis.
Genes Dev: 2009, 23(8);1014-24
[PubMed:19390092]
[WorldCat.org]
[DOI]
(I p)
Céline Karmazyn-Campelli, Lamya Rhayat, Rut Carballido-López, Sandra Duperrier, Niels Frandsen, Patrick Stragier
How the early sporulation sigma factor sigmaF delays the switch to late development in Bacillus subtilis.
Mol Microbiol: 2008, 67(5);1169-80
[PubMed:18208527]
[WorldCat.org]
[DOI]
(I p)
Oleg A Igoshin, Margaret S Brody, Chester W Price, Michael A Savageau
Distinctive topologies of partner-switching signaling networks correlate with their physiological roles.
J Mol Biol: 2007, 369(5);1333-52
[PubMed:17498739]
[WorldCat.org]
[DOI]
(P p)
Oleg A Igoshin, Chester W Price, Michael A Savageau
Signalling network with a bistable hysteretic switch controls developmental activation of the sigma transcription factor in Bacillus subtilis.
Mol Microbiol: 2006, 61(1);165-84
[PubMed:16824103]
[WorldCat.org]
[DOI]
(P p)
Stephanie T Wang, Barbara Setlow, Erin M Conlon, Jessica L Lyon, Daisuke Imamura, Tsutomu Sato, Peter Setlow, Richard Losick, Patrick Eichenberger
The forespore line of gene expression in Bacillus subtilis.
J Mol Biol: 2006, 358(1);16-37
[PubMed:16497325]
[WorldCat.org]
[DOI]
(P p)
Jonathan Dworkin, Richard Losick
Developmental commitment in a bacterium.
Cell: 2005, 121(3);401-9
[PubMed:15882622]
[WorldCat.org]
[DOI]
(P p)
Masaya Fujita, José Eduardo González-Pastor, Richard Losick
High- and low-threshold genes in the Spo0A regulon of Bacillus subtilis.
J Bacteriol: 2005, 187(4);1357-68
[PubMed:15687200]
[WorldCat.org]
[DOI]
(P p)
Joanna Clarkson, Iain D Campbell, Michael D Yudkin
Efficient regulation of sigmaF, the first sporulation-specific sigma factor in B.subtilis.
J Mol Biol: 2004, 342(4);1187-95
[PubMed:15351644]
[WorldCat.org]
[DOI]
(P p)
Karen Carniol, Tae-Jong Kim, Chester W Price, Richard Losick
Insulation of the sigmaF regulatory system in Bacillus subtilis.
J Bacteriol: 2004, 186(13);4390-4
[PubMed:15205443]
[WorldCat.org]
[DOI]
(P p)
Karen Carniol, Patrick Eichenberger, Richard Losick
A threshold mechanism governing activation of the developmental regulatory protein sigma F in Bacillus subtilis.
J Biol Chem: 2004, 279(15);14860-70
[PubMed:14744853]
[WorldCat.org]
[DOI]
(P p)
Margaret S Ho, Karen Carniol, Richard Losick
Evidence in support of a docking model for the release of the transcription factor sigma F from the antisigma factor SpoIIAB in Bacillus subtilis.
J Biol Chem: 2003, 278(23);20898-905
[PubMed:12676949]
[WorldCat.org]
[DOI]
(P p)
Ulrike Mäder, Georg Homuth, Christian Scharf, Knut Büttner, Rüdiger Bode, Michael Hecker
Transcriptome and proteome analysis of Bacillus subtilis gene expression modulated by amino acid availability.
J Bacteriol: 2002, 184(15);4288-95
[PubMed:12107147]
[WorldCat.org]
[DOI]
(P p)
Jennifer T Kemp, Adam Driks, Richard Losick
FtsA mutants of Bacillus subtilis impaired in sporulation.
J Bacteriol: 2002, 184(14);3856-63
[PubMed:12081956]
[WorldCat.org]
[DOI]
(P p)
J Dworkin, R Losick
Differential gene expression governed by chromosomal spatial asymmetry.
Cell: 2001, 107(3);339-46
[PubMed:11701124]
[WorldCat.org]
[DOI]
(P p)
Q Pan, D A Garsin, R Losick
Self-reinforcing activation of a cell-specific transcription factor by proteolysis of an anti-sigma factor in B. subtilis.
Mol Cell: 2001, 8(4);873-83
[PubMed:11684022]
[WorldCat.org]
[DOI]
(P p)
P Fawcett, P Eichenberger, R Losick, P Youngman
The transcriptional profile of early to middle sporulation in Bacillus subtilis.
Proc Natl Acad Sci U S A: 2000, 97(14);8063-8
[PubMed:10869437]
[WorldCat.org]
[DOI]
(P p)
E A Campbell, S A Darst
The anti-sigma factor SpoIIAB forms a 2:1 complex with sigma(F), contacting multiple conserved regions of the sigma factor.
J Mol Biol: 2000, 300(1);17-28
[PubMed:10864495]
[WorldCat.org]
[DOI]
(P p)
A Petersohn, S Engelmann, P Setlow, M Hecker
The katX gene of Bacillus subtilis is under dual control of sigmaB and sigmaF.
Mol Gen Genet: 1999, 262(1);173-9
[PubMed:10503549]
[WorldCat.org]
[DOI]
(P p)
N King, O Dreesen, P Stragier, K Pogliano, R Losick
Septation, dephosphorylation, and the activation of sigmaF during sporulation in Bacillus subtilis.
Genes Dev: 1999, 13(9);1156-67
[PubMed:10323866]
[WorldCat.org]
[DOI]
(P p)
N Frandsen, I Barák, C Karmazyn-Campelli, P Stragier
Transient gene asymmetry during sporulation and establishment of cell specificity in Bacillus subtilis.
Genes Dev: 1999, 13(4);394-9
[PubMed:10049355]
[WorldCat.org]
[DOI]
(P p)
D A Garsin, L Duncan, D M Paskowitz, R Losick
The kinase activity of the antisigma factor SpoIIAB is required for activation as well as inhibition of transcription factor sigmaF during sporulation in Bacillus subtilis.
J Mol Biol: 1998, 284(3);569-78
[PubMed:9826499]
[WorldCat.org]
[DOI]
(P p)
D A Garsin, D M Paskowitz, L Duncan, R Losick
Evidence for common sites of contact between the antisigma factor SpoIIAB and its partners SpoIIAA and the developmental transcription factor sigmaF in Bacillus subtilis.
J Mol Biol: 1998, 284(3);557-68
[PubMed:9826498]
[WorldCat.org]
[DOI]
(P p)
I Bagyan, L Casillas-Martinez, P Setlow
The katX gene, which codes for the catalase in spores of Bacillus subtilis, is a forespore-specific gene controlled by sigmaF, and KatX is essential for hydrogen peroxide resistance of the germinating spore.
J Bacteriol: 1998, 180(8);2057-62
[PubMed:9555886]
[WorldCat.org]
[DOI]
(P p)
K Pogliano, A E Hofmeister, R Losick
Disappearance of the sigma E transcription factor from the forespore and the SpoIIE phosphatase from the mother cell contributes to establishment of cell-specific gene expression during sporulation in Bacillus subtilis.
J Bacteriol: 1997, 179(10);3331-41
[PubMed:9150232]
[WorldCat.org]
[DOI]
(P p)
M Gomez, S M Cutting
Expression of the Bacillus subtilis spoIVB gene is under dual sigma F/sigma G control.
Microbiology (Reading): 1996, 142 ( Pt 12);3453-7
[PubMed:9004507]
[WorldCat.org]
[DOI]
(P p)
P J Lewis, T Magnin, J Errington
Compartmentalized distribution of the proteins controlling the prespore-specific transcription factor sigmaF of Bacillus subtilis.
Genes Cells: 1996, 1(10);881-94
[PubMed:9077448]
[WorldCat.org]
[DOI]
(P p)
A L Decatur, R Losick
Three sites of contact between the Bacillus subtilis transcription factor sigmaF and its antisigma factor SpoIIAB.
Genes Dev: 1996, 10(18);2348-58
[PubMed:8824593]
[WorldCat.org]
[DOI]
(P p)
A Decatur, R Losick
Identification of additional genes under the control of the transcription factor sigma F of Bacillus subtilis.
J Bacteriol: 1996, 178(16);5039-41
[PubMed:8759874]
[WorldCat.org]
[DOI]
(P p)
S Alper, A Dufour, D A Garsin, L Duncan, R Losick
Role of adenosine nucleotides in the regulation of a stress-response transcription factor in Bacillus subtilis.
J Mol Biol: 1996, 260(2);165-77
[PubMed:8764398]
[WorldCat.org]
[DOI]
(P p)
L Duncan, S Alper, R Losick
SpoIIAA governs the release of the cell-type specific transcription factor sigma F from its anti-sigma factor SpoIIAB.
J Mol Biol: 1996, 260(2);147-64
[PubMed:8764397]
[WorldCat.org]
[DOI]
(P p)
A Feucht, T Magnin, M D Yudkin, J Errington
Bifunctional protein required for asymmetric cell division and cell-specific transcription in Bacillus subtilis.
Genes Dev: 1996, 10(7);794-803
[PubMed:8846916]
[WorldCat.org]
[DOI]
(P p)
L Duncan, S Alper, F Arigoni, R Losick, P Stragier
Activation of cell-specific transcription by a serine phosphatase at the site of asymmetric division.
Science: 1995, 270(5236);641-4
[PubMed:7570023]
[WorldCat.org]
[DOI]
(P p)
C D Webb, A Decatur, A Teleman, R Losick
Use of green fluorescent protein for visualization of cell-specific gene expression and subcellular protein localization during sporulation in Bacillus subtilis.
J Bacteriol: 1995, 177(20);5906-11
[PubMed:7592342]
[WorldCat.org]
[DOI]
(P p)
E J Harry, K Pogliano, R Losick
Use of immunofluorescence to visualize cell-specific gene expression during sporulation in Bacillus subtilis.
J Bacteriol: 1995, 177(12);3386-93
[PubMed:7768847]
[WorldCat.org]
[DOI]
(P p)
R Schuch, P J Piggot
The dacF-spoIIA operon of Bacillus subtilis, encoding sigma F, is autoregulated.
J Bacteriol: 1994, 176(13);4104-10
[PubMed:8021191]
[WorldCat.org]
[DOI]
(P p)
P J Lewis, S R Partridge, J Errington
Sigma factors, asymmetry, and the determination of cell fate in Bacillus subtilis.
Proc Natl Acad Sci U S A: 1994, 91(9);3849-53
[PubMed:8171000]
[WorldCat.org]
[DOI]
(P p)
S Alper, L Duncan, R Losick
An adenosine nucleotide switch controlling the activity of a cell type-specific transcription factor in B. subtilis.
Cell: 1994, 77(2);195-205
[PubMed:8168129]
[WorldCat.org]
[DOI]
(P p)
D Foulger, J Errington
Effects of new mutations in the spoIIAB gene of Bacillus subtilis on the regulation of sigma F and sigma G activities.
J Gen Microbiol: 1993, 139(12);3197-203
[PubMed:8126438]
[WorldCat.org]
[DOI]
(P p)
K T Min, C M Hilditch, B Diederich, J Errington, M D Yudkin
Sigma F, the first compartment-specific transcription factor of B. subtilis, is regulated by an anti-sigma factor that is also a protein kinase.
Cell: 1993, 74(4);735-42
[PubMed:8358793]
[WorldCat.org]
[DOI]
(P p)
L Duncan, R Losick
SpoIIAB is an anti-sigma factor that binds to and inhibits transcription by regulatory protein sigma F from Bacillus subtilis.
Proc Natl Acad Sci U S A: 1993, 90(6);2325-9
[PubMed:8460142]
[WorldCat.org]
[DOI]
(P p)
J J Wu, R Schuch, P J Piggot
Characterization of a Bacillus subtilis sporulation operon that includes genes for an RNA polymerase sigma factor and for a putative DD-carboxypeptidase.
J Bacteriol: 1992, 174(15);4885-92
[PubMed:1629150]
[WorldCat.org]
[DOI]
(P p)
K York, T J Kenney, S Satola, C P Moran, H Poth, P Youngman
Spo0A controls the sigma A-dependent activation of Bacillus subtilis sporulation-specific transcription unit spoIIE.
J Bacteriol: 1992, 174(8);2648-58
[PubMed:1556084]
[WorldCat.org]
[DOI]
(P p)
D Sun, P Fajardo-Cavazos, M D Sussman, F Tovar-Rojo, R M Cabrera-Martinez, P Setlow
Effect of chromosome location of Bacillus subtilis forespore genes on their spo gene dependence and transcription by E sigma F: identification of features of good E sigma F-dependent promoters.
J Bacteriol: 1991, 173(24);7867-74
[PubMed:1744043]
[WorldCat.org]
[DOI]
(P p)
P Margolis, A Driks, R Losick
Establishment of cell type by compartmentalized activation of a transcription factor.
Science: 1991, 254(5031);562-5
[PubMed:1948031]
[WorldCat.org]
[DOI]
(P p)
N Illing, J Errington
Genetic regulation of morphogenesis in Bacillus subtilis: roles of sigma E and sigma F in prespore engulfment.
J Bacteriol: 1991, 173(10);3159-69
[PubMed:1902463]
[WorldCat.org]
[DOI]
(P p)
S R Partridge, D Foulger, J Errington
The role of sigma F in prespore-specific transcription in Bacillus subtilis.
Mol Microbiol: 1991, 5(3);757-67
[PubMed:1904527]
[WorldCat.org]
[DOI]
(P p)
R Schmidt, P Margolis, L Duncan, R Coppolecchia, C P Moran, R Losick
Control of developmental transcription factor sigma F by sporulation regulatory proteins SpoIIAA and SpoIIAB in Bacillus subtilis.
Proc Natl Acad Sci U S A: 1990, 87(23);9221-5
[PubMed:2123551]
[WorldCat.org]
[DOI]
(P p)
J J Wu, M G Howard, P J Piggot
Regulation of transcription of the Bacillus subtilis spoIIA locus.
J Bacteriol: 1989, 171(2);692-8
[PubMed:2492512]
[WorldCat.org]
[DOI]
(P p)
J Errington, J Mandelstam
Use of a lacZ gene fusion to determine the dependence pattern of sporulation operon spoIIA in spo mutants of Bacillus subtilis.
J Gen Microbiol: 1986, 132(11);2967-76
[PubMed:3114419]
[WorldCat.org]
[DOI]
(P p)
M D Yudkin
The sigma-like product of sporulation gene spoIIAC of Bacillus subtilis is toxic to Escherichia coli.
Mol Gen Genet: 1986, 202(1);55-7
[PubMed:3007937]
[WorldCat.org]
[DOI]
(P p)