PTS

The PEP:Sugar Phosphotransferase System

The PTS is a sugar transport system that couples the transport of a sugar to its phosphorylation. The phosphate group is derived from phosphoenolpyruvate (PEP) and transferred via the general PTS proteins Enzyme I (EI) and HPr to the substrate-specific Enzymes II (EII) to the incoming sugars.

In addition to its role in sugar transport, the PTS is also involved in the regulation of carbon metabolism.

General PTS proteins

• Enzyme I
• HPr

Sugar specific PTS proteins

• PtsG: glucose permease, EIICBA
• GamP: glucosamine permease, EIICBA
• MurP: N-acetyl muramic acid-specific phosphotransferase system, EIIBC component
• MtlA, MtlF: mannitol permease
• GmuA, GmuB, GmuC: galactomannan permease
• TreP: trehalose permease
• MalP: maltose permease
• FruA: fructose permease
• ManP: mannose permease
• YpqE: unknown EIIA component
• LevD, LevE, LevF, LevG: fructose permease
• SacP: sucrose permease (high affinity)
• SacY: sucrose permease (low affinity)
• LicA, LicB, LicC: lichenan permease
• BglP: ß-glucoside permease
• YyzE: unknown PTS protein
• MtlF
• YwbA: unknown EIIC component

Proteins closely related to the PTS

• Crh: HPr-like protein with exculsively regulatory functions (His-15 is not conserved
• HprK: HPr-kinase, key factor for carbon catabolite repression

Non-PTS proteins controlled by PTS-dependent phosphorylation

• PRD-containing transcription factors
• GlpK

The PTS in SubtiPathways

• Central C-metabolism
• Sugar catabolism

Related Lists

• PRD-containing transcription factors
• transport proteins
• trigger enzymes