Difference between revisions of "MurG"
| Line 95: | Line 95: | ||
=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' [[murE]]-[[mraY]]-[[murD]]-[[spoVE]]-[[murG]]-[[murB]]-[[divIB]]-[[ylxW]]-[[ylxX]]-[[sbp]] | + | * '''Operon:''' |
| + | ** ''[[murE]]-[[mraY]]-[[murD]]-[[spoVE]]-[[murG]]-[[murB]]-[[divIB]]-[[ylxW]]-[[ylxX]]-[[sbp]]'' {{PubMed|1391053}} | ||
| + | ** ''[[spoVE]]-[[murG]]-[[murB]]-[[divIB]]-[[ylxW]]-[[ylxX]]-[[sbp]]'' {{PubMed|1391053}} | ||
| − | * '''[[Sigma factor]]:''' [[SigE]] | + | * '''[[Sigma factor]]:''' |
| + | ** ''[[spoVE]]'': [[SigE]] {{PubMed|8320223}} | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** expressed during vegatative growth, then switched off, and again expressed during sporulation in the mother cell ([[SigE]]) {{PubMed|1391053}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[SpoIIID]]: transcription repression {{PubMed|15383836}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
| Line 125: | Line 130: | ||
=References= | =References= | ||
| − | <pubmed>,18063720,18081839, </pubmed> | + | <pubmed>,18063720,18081839, 1391053 8320223 15383836</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 12:05, 10 October 2009
- Description: UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
| Gene name | murG |
| Synonyms | |
| Essential | yes PubMed |
| Product | UDP-N-acetylglucosamine-
N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase |
| Function | peptidoglycan precursor biosynthesis |
| Metabolic function and regulation of this protein in SubtiPathways: Cell wall | |
| MW, pI | 39 kDa, 9.568 |
| Gene length, protein length | 1089 bp, 363 aa |
| Immediate neighbours | spoVE, murB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU15220
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol (according to Swiss-Prot)
- Protein family: MurG subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P37585
- KEGG entry: [3]
- E.C. number: 2.4.1.227
Additional information
Expression and regulation
- Operon:
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
