Papers of the month - Revision history

Jstuelk at 12:27, 15 February 2024

2024-02-15T12:27:15Z

Jstuelk at 12:19, 15 February 2024

2024-02-15T12:19:09Z

Jstuelk: /* 2024 */

2024-02-15T10:53:00Z

‎2024

Jstuelk at 10:05, 15 January 2024

2024-01-15T10:05:39Z

Jstuelk at 14:23, 10 January 2024

2024-01-10T14:23:16Z

Jstuelk: /* 2023 */

2023-12-21T11:02:13Z

‎2023

Jstuelk: /* 2023 */

2023-10-24T14:48:42Z

‎2023

Jstuelk: /* 2023 */

2023-10-24T14:37:46Z

‎2023

Jstuelk: /* 2023 */

2023-10-09T16:47:31Z

‎2023

Jstuelk: /* 2023 */

2023-05-24T14:03:56Z

‎2023

@@ Line 1: / Line 1: @@
 =2024=
 * '''February 2024'''
-** This is the month of [[Translation factors]]. The group of [[Heather Feaga]] has identified the ABCF ATPase [[YfmR]] as a protein that is essential to rescue ribosomes stalled at polyproline stretches in the absence of [[Efp]]. Similar results on the resolution of stalled ribosomes by [[YfmR]] and [[YkpA]] are also reported in a [https://www.biorxiv.org/content/biorxiv/early/2024/01/26/2024.01.25.577322.full.pdf preprint] from the group of [[Vasili Hauryliuk]]. Moreover, the so far unknown stress protein [[YocB]] is a novel hibernation factor that interacts with [[TufA]] to to inhibit protein synthesis and protect their ribosomes from damage.
+** This is the month of [http://www.subtiwiki.uni-goettingen.de/wiki//index.php/Translation#Translation_factors translation factors]. The group of [[Heather Feaga]] has identified the ABCF ATPase [[YfmR]] as a protein that is essential to rescue ribosomes stalled at polyproline stretches in the absence of [[Efp]]. Similar results on the resolution of stalled ribosomes by [[YfmR]] and [[YkpA]] are also reported in a [https://www.biorxiv.org/content/biorxiv/early/2024/01/26/2024.01.25.577322.full.pdf preprint] from the group of [[Vasili Hauryliuk]]. Moreover, the so far unknown stress protein [[YocB]] is a novel hibernation factor that interacts with [[TufA]] to to inhibit protein synthesis and protect their ribosomes from damage.
-** '''Relevant ''Subti''Wiki pages:''' [[Heather Feaga]], [[Vasili Hauryliuk]], [[Translation factors]], [[YfmR]], [[YkpA]], [[YocB]]
+** '''Relevant ''Subti''Wiki pages:''' [[Heather Feaga]], [[Vasili Hauryliuk]], [http://www.subtiwiki.uni-goettingen.de/wiki//index.php/Translation#Translation_factors translation factors], [[YfmR]], [[YkpA]], [[YocB]]
 <pubmed> 38355796 ,38349882</pubmed>

@@ Line 1: / Line 1: @@
 =2024=
 * '''February 2024'''
-** This is the month of [[translation factors]]. The group of Heather Feaga has identified the ABCF ATPase [[YfmR]] as a protein that is essential to rescue ribosomes stalled at polypro line stretches in the absence of [[Efp]]. Moreover, the so far unknown stress protein YocB is a novel hibernation factor that interacts with TufA to
+** This is the month of [[Translation factors]]. The group of [[Heather Feaga]] has identified the ABCF ATPase [[YfmR]] as a protein that is essential to rescue ribosomes stalled at polyproline stretches in the absence of [[Efp]]. Similar results on the resolution of stalled ribosomes by [[YfmR]] and [[YkpA]] are also reported in a [https://www.biorxiv.org/content/biorxiv/early/2024/01/26/2024.01.25.577322.full.pdf preprint] from the group of [[Vasili Hauryliuk]]. Moreover, the so far unknown stress protein [[YocB]] is a novel hibernation factor that interacts with [[TufA]] to to inhibit protein synthesis and protect their ribosomes from damage.
-** '''Relevant ''Subti''Wiki pages:''' [[Avigdor Eldar]], [[Wilfried Meijer]], [[AimX]], [[AimR]], [[YosL]], [[MazE]], [[MazF]]
+** '''Relevant ''Subti''Wiki pages:''' [[Heather Feaga]], [[Vasili Hauryliuk]], [[Translation factors]], [[YfmR]], [[YkpA]], [[YocB]]
-<pubmed>38177302 ,38177304</pubmed>
+<pubmed> 38355796 ,38349882</pubmed>
 * '''January 2024'''

@@ Line 1: / Line 1: @@
 =2024=
 * '''January 2024'''
 ** Temperate ''Bacillus'' phages often use the small-molecule arbitrium communication system to control lysis/lysogeny decisions, but the underlying mechanisms remain largely unknown. Now, two studies show that the arbitrium system of ''B. subtilis'' phage ϕ3T modulates the host-encoded [[MazE]]-[[MazF]] toxin-antitoxin system to regulate the phage life cycle. Upon infection, the [[MazF]] ribonuclease is activated by three phage genes. At low arbitrium signal concentrations, [[MazF]] is inactivated by two phage-encoded [[MazE]] homologues, the arbitrium-controlled [[AimX]] and the later-expressed [[YosL]] proteins. The results show how a bacterial toxin-antitoxin system has been co-opted by a phage to control lysis/lysogeny decisions without compromising host viability.

@@ Line 2: / Line 2: @@
 * '''January 2024'''
 ** Temperate ''Bacillus'' phages often use the small-molecule arbitrium communication system to control lysis/lysogeny decisions, but the underlying mechanisms remain largely unknown. Now, two studies show that the arbitrium system of ''B. subtilis'' phage ϕ3T modulates the host-encoded [[MazE]]-[[MazF]] toxin-antitoxin system to regulate the phage life cycle. Upon infection, the [[MazF]] ribonuclease is activated by three phage genes. At low arbitrium signal concentrations, [[MazF]] is inactivated by two phage-encoded [[MazE]] homologues, the arbitrium-controlled [[AimX]] and the later-expressed [[YosL]] proteins. The results show how a bacterial toxin-antitoxin system has been co-opted by a phage to control lysis/lysogeny decisions without compromising host viability.
-** '''Relevant ''Subti''Wiki pages:''' [[Avigdor Eldar]], [ilfried Meijer], [[AimX]], [[AimR]], [[YosL]], [[MazE]], [[MazF]]
+** '''Relevant ''Subti''Wiki pages:''' [[Avigdor Eldar]], [[Wilfried Meijer]], [[AimX]], [[AimR]], [[YosL]], [[MazE]], [[MazF]]
 <pubmed>38177302 ,38177304</pubmed>

← Older revision		Revision as of 14:23, 10 January 2024
Line 1:		Line 1:
		+	=2024=
		+	* '''January 2024'''
		+	** Temperate ''Bacillus'' phages often use the small-molecule arbitrium communication system to control lysis/lysogeny decisions, but the underlying mechanisms remain largely unknown. Now, two studies show that the arbitrium system of ''B. subtilis'' phage ϕ3T modulates the host-encoded [[MazE]]-[[MazF]] toxin-antitoxin system to regulate the phage life cycle. Upon infection, the [[MazF]] ribonuclease is activated by three phage genes. At low arbitrium signal concentrations, [[MazF]] is inactivated by two phage-encoded [[MazE]] homologues, the arbitrium-controlled [[AimX]] and the later-expressed [[YosL]] proteins. The results show how a bacterial toxin-antitoxin system has been co-opted by a phage to control lysis/lysogeny decisions without compromising host viability.
		+	** '''Relevant ''Subti''Wiki pages:''' [[Avigdor Eldar]], [ilfried Meijer], [[AimX]], [[AimR]], [[YosL]], [[MazE]], [[MazF]]
		+	<pubmed>38177302 ,38177304</pubmed>
		+
	=2023=		=2023=
	* '''December 2023'''		* '''December 2023'''

@@ Line 1: / Line 1: @@
 =2023=
 * '''October 2023'''
 ** ''B. subtilis'' spores are metabolically dormant and resistant to microbicides, while germinated spores are easy to kill. Thus, understanding germination may facilitate the development of "germinate-to-eradicate" strategies. A recent high-profile paper [Science (2022) 378:43] (POTM October 2022) suggested that increasing spore electrochemical potential is how memory is "stored" based on measurements of accumulation of the dye thioflavin-T after germinant exposure. Now,[https://journals.asm.org/doi/10.1128/mbio.02220-23 Li et al.] challenge this view and show that inferring spores' electrochemical potential from thioflavin-T accumulation is problematic. Thioflavin-T accumulation during the early stages of germination is due to its binding to the spore coat rather than to changes in spores' electrochemical potential. Thus, using thioflavin-T uptake by germinating spores to assess the involvement of electrochemical potential in memory of germinant exposure, as suggested recently, is questionable.

@@ Line 1: / Line 1: @@
 =2023=
 * '''September 2023'''
 ** Cell wall synthesis requires an interplay of breaking old and making new bonds in peptidoglycan. Due to their redundancy, it has been difficult so far, to study the function of individual cell wall hydrolyses. Now, [https://journals.asm.org/doi/10.1128/mbio.01760-23 Wilson et al.] from the labs of [[Ethan Garner]] and [[Simon Foster]] have deleted 40 potential hydrolyses, keeping only [[LytE]] and [[CwlO]]. Each of these hydrolases is still dispensable in the deletion strain. The study demonstrates that the only essential function of cell wall hydrolases in ''B. subtilis'' is to enable cell growth by expanding the wall and that [[LytE]] or [[CwlO]] alone are sufficient for this function.

@@ Line 1: / Line 1: @@
 =2023=
 * '''May 2023'''
 ** Two recent papers provide an excellent overview on new developments in the functional annotation of the ''B. subtilis'' genome and on the use of ''B. subtilis'' as a model organism in research and a workhorse in biotechnology.

@@ Line 1: / Line 1: @@
 =2023=
 * '''April 2023'''
 ** ''B. subtilis'' spores are able to resist a variety of hostile conditions and can remain metabolically inactive for centuries. In the presence of nutrients, the spores can initiate germination in minutes. How the inactive spores detect the nutrients and start outgrowth, has remained a matter of debate. Now, [https://www.science.org/doi/10.1126/science.adg9829 Gao et al.] from the lab of [[David Rudner]] discovered that germinant receptors embedded in the spore membrane oligomerize into nutrient-gated ion channels and then ion release triggers exit from dormancy.