Main Page - Revision history

Jstuelk at 10:15, 22 February 2017

2017-02-22T10:15:28Z

Jstuelk at 10:12, 22 February 2017

2017-02-22T10:12:15Z

Jstuelk at 17:47, 21 February 2017

2017-02-21T17:47:12Z

Jstuelk at 13:16, 10 August 2015

2015-08-10T13:16:30Z

Jstuelk at 13:14, 10 August 2015

2015-08-10T13:14:56Z

Jstuelk at 08:30, 6 August 2015

2015-08-06T08:30:05Z

Jstuelk at 11:10, 23 July 2015

2015-07-23T11:10:42Z

Jstuelk at 08:48, 18 June 2015

2015-06-18T08:48:58Z

Jstuelk at 08:48, 18 June 2015

2015-06-18T08:48:34Z

Jstuelk at 08:51, 4 June 2015

2015-06-04T08:51:28Z

@@ Line 16: / Line 16: @@
 <br/>
-<big>'''Now online: A new description of ''Subti''Wiki and its acompanying modules in the [http://nar.oxfordjournals.org/content/40/D1/D1278.full.pdf+html 2014 Database issue of Nucleic Acids Research]'''</big>
+<big>'''Now online: A new description of ''Subti''Wiki and its acompanying modules in the [https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkv1006 2016 Database issue of Nucleic Acids Research]'''</big>
 <pubmed> 24178028 </pubmed>

@@ Line 8: / Line 8: @@
 <br/>
 <big>'''Upcoming events:'''</big>
-* The [http://www.grampositiveconference.org/  8th International Conference on Gram-positive Microorganisms] (18th International Conference on Bacilli) in Montecatini Terme, organized by [[Marta Perego]] will take place from June 21 to 25. [http://www.grampositiveconference.org/registration.html Conference website]
+* The [http://www.bacillus-2017.de/ 19th International Conference on Bacilli & Gram-Positive Bacteria] organized by [[Jörg Stülke]] will take place from June 11 to June 15, 2017, in Berlin, Germany. [http://www.bacillus-2017.de/ Conference website]
 * [[Past conferences]]

@@ Line 50: / Line 50: @@
 |width="300"|<big>'''Additional pages'''</big>
 |- style="height:20px"
-| ''[[spo0A]]'' || '''[http://subtiwiki.uni-goettingen.de/subtipathways/start.php ''Subti''Pathways]'''
+| ''[[spo0A]]'' || '''[[template]]'''
 |-
-| ''[[glnA]]'' ||  '''[http://subtiwiki.uni-goettingen.de/interact/ SubtInteract]'''
+| ''[[glnA]]'' ||  '''[[the people behind SubtiWiki|the people behind ''Subti''Wiki]]'''
 |-
-| ''[[rny]]'' ||  '''[http://subtiwiki.uni-goettingen.de/apps/expression/ SubtiExpress]'''
+| ''[[rny]]'' ||  '''[[labs working on Bacillus|labs working on ''Bacillus'']]'''
 |-
 | ''[[psdA]]'' || '''[[Regulons]]'''
@@ Line 69: / Line 69: @@
 |-
 | ''[[mreC]]'' || '''[[labs working on Bacillus|labs working on ''Bacillus'']]'''
 |-
 |  ||

@@ Line 21: / Line 21: @@
 <br/>
-<big>'''Paper of the month: July 2015'''</big>
+<big>'''Paper of the month: August 2015'''</big>
 * The cells in a biofilm experience very different conditions: While the inner cells are well protected from any harm from the environment, they have on the other hand only poor access to nutrients. For the cells on the edge of the biofilm, it is just the other way round. Now, [http://www.ncbi.nlm.nih.gov/pubmed/26200335 Liu et al.] from the lab of [[Gürol M. Süel]] have discovered oscillation in the [[biofilm formation|growth of the biofilm]]. These oscillations serve to provide the inner cells with access to nutrients. These oscillations are caused by metabolic co-dependence between cells in the biofilm periphery and interior that is driven by [[glutamate metabolism|glutamate consumption and ammonium production]], respectively.
 * '''Relevant ''Subti''Wiki pages:''' [[Gürol M. Süel]], [[glutamate metabolism|glutamate consumption and ammonium production]], [[biofilm formation]]

@@ Line 22: / Line 22: @@
 <br/>
 <big>'''Paper of the month: July 2015'''</big>
-* The precise functions of serine [[Protein kinases and phosphatases|protein kinases]] in ''B. subtilis'' have largely remained enigmatic until very recently. Now, two studies from the lab of [[Jonathan Dworkin]] describe functions and molecular targets for two of these kinases, [[PrkC]] and [[YabT]]. [http://www.ncbi.nlm.nih.gov/pubmed/26056311 Pereira et al.] have identified the universally conserved [[TufA|elongation factor Tu]] as a target for the protein kinase [[YabT]]. In srarving cells, YabT phosphorylates [[TufA|EF-Tu]] at a conserved threonine residue. Phosphorylation impairs the essential GTPase activity of [[TufA|EF-Tu]], thereby preventing its release from the [[ribosome]]. As a consequence, phosphorylated [[TufA|EF-Tu]] has a dominant-negative effect in [[translation]] elongation, resulting in the overall inhibition of protein synthesis. Importantly, this mechanism allows a quick and robust regulation of one of the [[most abundant proteins|most abundant cellular proteins]]. [http://www.ncbi.nlm.nih.gov/pubmed/26102633 Libby et al.] have uncovered that phosphorylation by PrkC stimulates the activity of the [[essential genes|essential]] [[Two-component systems|two-component transcription factor]] [[WalR]]. This mechanism links the presence of muropeptides that trigger [[PrkC]] activity to the expression of the genes of the [[WalR regulon]] that are involved in [[cell wall synthesis|cell wall metabolism]].
+* The cells in a biofilm experience very different conditions: While the inner cells are well protected from any harm from the environment, they have on the other hand only poor access to nutrients. For the cells on the edge of the biofilm, it is just the other way round. Now, [http://www.ncbi.nlm.nih.gov/pubmed/26200335 Liu et al.] from the lab of [[Gürol M. Süel]] have discovered oscillation in the [[biofilm formation|growth of the biofilm]]. These oscillations serve to provide the inner cells with access to nutrients. These oscillations are caused by metabolic co-dependence between cells in the biofilm periphery and interior that is driven by [[glutamate metabolism|glutamate consumption and ammonium production]], respectively.
-* '''Relevant ''Subti''Wiki pages:''' [[Jonathan Dworkin]], [[Protein kinases and phosphatases|protein kinases]], [[YabT]], [[TufA|EF-Tu]], [[PrkC]], [[WalR]], [[cell wall synthesis|cell wall metabolism]]
+* '''Relevant ''Subti''Wiki pages:''' [[Gürol M. Süel]], [[glutamate metabolism|glutamate consumption and ammonium production]], [[biofilm formation]]
-<pubmed>26056311 26102633</pubmed>
+* see [http://microbepost.org/2015/08/05/conflict-and-co-operation-in-bacterial-communities/ a blog presenting this paper]
 * [[Previous papers of the month]]

@@ Line 20: / Line 20: @@
 <br/>
-<big>'''Paper of the month: May 2015'''</big>
+<big>'''Paper of the month: June 2015'''</big>
 * The precise quantification of the dynamic changes in metabolite concentrations is a major challenge in metabolomics. Two new studies make use of the combination of metablite-sensitive riboswitches with an ''in vitro'' selected Spinach aptamer, which binds a pro-fluorescent, cell-permeable small molecule mimic of the GFP chromophore. Fluorescence can then be determined as a measure of the concentration of the metabolite that binds the riboswitch. The present studies use this approach for the essential second messenger c-di-AMP as well as for S-adenosyl-methionine and guanine.
 ** '''Relevant ''Subti''Wiki pages:''' [[riboswitch]], [[metabolism]], [[methods]]
-<pubmed25964329 25965978</pubmed>
+<pubmed> 25964329 25965978</pubmed>
 * [[Previous papers of the month]]