BdbC - Revision history

Jstuelk: /* References */

2014-09-19T10:41:21Z

‎References

134.76.70.252 at 11:44, 8 April 2014

2014-04-08T11:44:40Z

134.76.38.147 at 14:45, 2 April 2014

2014-04-02T14:45:17Z

134.76.70.252 at 14:34, 16 May 2013

2013-05-16T14:34:22Z

134.76.70.252 at 11:16, 14 May 2013

2013-05-14T11:16:00Z

134.76.70.252 at 13:50, 13 May 2013

2013-05-13T13:50:44Z

134.76.70.252 at 15:55, 7 August 2012

2012-08-07T15:55:21Z

Jstuelk at 14:40, 6 May 2012

2012-05-06T14:40:46Z

Jstuelk at 14:23, 6 May 2012

2012-05-06T14:23:41Z

134.76.70.252 at 09:09, 23 April 2012

2012-04-23T09:09:02Z

← Older revision		Revision as of 10:41, 19 September 2014
Line 1:		Line 1:
−	* '''Description:~~''' thiol-disulfide oxidoreductase, required for the formation of thiol disulfide bonds in several proteins <br/><br/>~~	+	{{#bank: BdbC}}

−	~~{\| align="right" border="1" cellpadding="2"~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Gene name'''~~
−	~~\|''bdbC''~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Synonyms''' \|\| ''yvgU ''~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Essential''' \|\| no~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Product''' \|\| thiol-disulfide oxidoreductase~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Function''' \|\| oxidative folding of proteins~~
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33470 bdbC]
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Metabolic function and regulation of this protein in [[SubtiPathways\|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=BdbC BdbC]'''
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''MW, pI''' \|\| 15 kDa, 9.054~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Gene length, protein length''' \|\| 414 bp, 138 aa~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Immediate neighbours''' \|\| ''[[yvgT]]'', ''[[bdbD]]''~~
−	\|-
−	\|style="background:#FAF8CC;" align="center"\|'''Sequences'''\|\|[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU33470 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU33470 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU33470 DNA_with_flanks]
−	\|-
−	~~\|colspan="2" \| '''Genetic context''' <br/> [[Image:bdbC_context.gif]]~~
−	~~<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>~~
−	\|-
−	\|colspan="2" \|'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=bdbC_3437644_3438060_-1 Expression at a glance]'''   {{PubMed\|22383849}}<br/>[[Image:bdbC_expression.png\|500px\|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33470]]
−	\|-
−	\|}
−
−	~~__TOC__~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/>~~
−
−	~~= [[Categories]] containing this gene/protein =~~
−	~~{{SubtiWiki category\|[[genetic competence]]}},~~
−	~~{{SubtiWiki category\|[[chaperones/ protein folding]]}},~~
−	~~{{SubtiWiki category\|[[sporulation proteins]]}},~~
−	~~{{SubtiWiki category\|[[membrane proteins]]}}~~
−
−	~~= This gene is a member of the following [[regulons]] =~~
−	~~{{SubtiWiki regulon\|[[ComK regulon]]}},~~
−	~~{{SubtiWiki regulon\|[[SigE regulon]]}}~~
−
−	~~=The gene=~~
−
−	~~=== Basic information ===~~
−
−	* '''Locus tag:''' BSU33470
−
−	~~===Phenotypes of a mutant ===~~
−	* loss of transformability [http://www.ncbi.nlm.nih.gov/sites/entrez/11744713 PubMed]
−	* sensitive to osmotic shock {{PubMed\|22540663}}
−	* several proteins are absent from the membrane proteome of a ''[[bdbC]]-[[bdbD]]'' mutant: {{PubMed\|22540663}}
−	** the membrane proteins [[BglP]], [[TcyP]], [[SipU]], [[LytA]], and [[YxaI]] {{PubMed\|22540663}}
−	** the cytoplasmic or membrane-associated proteins [[GlkX]], [[ProA]], [[PyrAA]], [[PyrAB]], [[PyrH]], [[PyrE]], [[PyrF]], [[DegS]], [[YbxA]] {{PubMed\|22540663}}
−
−	~~=== Database entries ===~~
−	* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU33470&redirect=T BSU33470]
−
−	* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/bdbDC.html]
−
−	* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG14103]
−
−	~~=== Additional information===~~
−
−
−	~~=The protein=~~
−
−	~~=== Basic information/ Evolution ===~~
−
−	* '''Catalyzed reaction/ biological activity:'''
−	** formation of thiol disulfide bonds in [[ComEC]] and [[ComGC]] (together with [[BdbD]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/11744713 PubMed]
−	** oxidative folding of [[SunA]] (together with [[BdbB]])
−
−	* '''Protein family:''' BdbC subfamily (according to Swiss-Prot)
−
−	* '''Paralogous protein(s):'''
−
−	~~=== Extended information on the protein ===~~
−
−	* '''Kinetic information:'''
−
−	* '''Domains:'''
−
−	* '''Modification:'''
−
−	* '''Cofactor(s):'''
−
−	* '''Effectors of protein activity:'''
−
−	* '''[[SubtInteract\|Interactions]]:'''
−
−	* '''[[Localization]]:''' cell membrane (according to Swiss-Prot)
−
−	~~=== Database entries ===~~
−	* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU33470&redirect=T BSU33470]
−
−	* '''Structure:'''
−
−	* '''UniProt:''' [http://www.uniprot.org/uniprot/O32217 O32217]
−
−	* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU33470]
−
−	* '''E.C. number:'''
−
−	~~=== Additional information===~~
−
−	~~=Expression and regulation=~~
−	* '''Operon:''' ''[[bdbD]]-[[bdbC]]'' {{PubMed\|11744713}}
−
−	* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=bdbC_3437644_3438060_-1 bdbC] {{PubMed\|22383849}}
−
−	* '''Sigma factor:''' [[SigE]] {{PubMed\|12480901}}
−
−	* '''Regulation:'''
−	** expressed early during sporulation in the mother cell ([[SigE]]) {{PubMed\|12480901}}
−
−	* '''Regulatory mechanism:'''
−	** [[ComK]]: transcription activation {{PubMed\|11744713}}
−
−	* '''Additional information:'''
−
−	~~=Biological materials =~~
−
−	* '''Mutant:'''
−
−	* '''Expression vector:'''
−
−	* '''lacZ fusion:'''
−
−	* '''GFP fusion:'''
−
−	* '''two-hybrid system:'''
−
−	* '''Antibody:'''
−
−	~~=Labs working on this gene/protein=~~
−
−	~~=Your additional remarks=~~
−
−	~~=References=~~
−
−	~~<pubmed>11744713,15661011,11872755,17088376,16751195,11844773,12480901 , 22540663 </pubmed>~~
−
−	~~[[Category:Protein-coding genes]]~~

@@ Line 16: / Line 16: @@
 |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33470 bdbC]
 |-
-|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]'''
+|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in  [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=BdbC BdbC]'''
 |-
 |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 15 kDa, 9.054

@@ Line 64: / Line 64: @@
 === Database entries ===
 * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/bdbDC.html]
@@ Line 101: / Line 102: @@
 === Database entries ===
 * '''Structure:'''

@@ Line 29: / Line 29: @@
   <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 |-
-|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=bdbC_3437644_3438060_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:bdbC_expression.png|500px]]
+|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=bdbC_3437644_3438060_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:bdbC_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33470]]
 |-
 |}

@@ Line 24: / Line 24: @@
 |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yvgT]]'', ''[[bdbD]]''
 |-
-|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU33470 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU33470 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU33470 Advanced_DNA]
+|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU33470 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU33470 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU33470 DNA_with_flanks]
 |-
 |colspan="2" | '''Genetic context''' <br/> [[Image:bdbC_context.gif]]

@@ Line 13: / Line 13: @@
 |-
 |style="background:#ABCDEF;" align="center"|'''Function''' || oxidative folding of proteins
 |-
 |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]'''

@@ Line 12: / Line 12: @@
 |style="background:#ABCDEF;" align="center"| '''Product''' || thiol-disulfide oxidoreductase
 |-
-|style="background:#ABCDEF;" align="center"|'''Function''' || genetic transformation
+|style="background:#ABCDEF;" align="center"|'''Function''' || oxidative folding of proteins
 |-
 |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]'''
@@ Line 36: / Line 36: @@
 <br/><br/><br/><br/>
 <br/><br/><br/><br/>
 <br/><br/>
@@ Line 58: / Line 55: @@
 ===Phenotypes of a mutant ===
+* loss of transformability [http://www.ncbi.nlm.nih.gov/sites/entrez/11744713 PubMed]
-loss of transformability [http://www.ncbi.nlm.nih.gov/sites/entrez/11744713 PubMed]
+* sensitive to osmotic shock {{PubMed|22540663}}
 === Database entries ===
@@ Line 68: / Line 68: @@
 === Additional information===
@@ Line 147: / Line 145: @@
 =References=
-<pubmed>11744713,15661011,11872755,17088376,16751195,11844773,12480901 , </pubmed>
+<pubmed>11744713,15661011,11872755,17088376,16751195,11844773,12480901 , 22540663 </pubmed>
 [[Category:Protein-coding genes]]

@@ Line 1: / Line 1: @@
-* '''Description:''' thiol-disulfide oxidoreductase, required for the formation of thiol disulfide bonds in [[ComGC]] <br/><br/>
+* '''Description:''' thiol-disulfide oxidoreductase, required for the formation of thiol disulfide bonds in several proteins <br/><br/>
 {| align="right" border="1" cellpadding="2"
@@ Line 76: / Line 76: @@
 === Basic information/ Evolution ===
-* '''Catalyzed reaction/ biological activity:''' formation of thiol disulfide bonds in [[ComGC]] [http://www.ncbi.nlm.nih.gov/sites/entrez/11744713 PubMed]
+* '''Catalyzed reaction/ biological activity:'''
 * '''Protein family:''' BdbC subfamily (according to Swiss-Prot)