View source for Sr1

* '''Description:''' [[small RNAs|small regulatory RNA]] controlling ''[[ahrC]]'' expression, peptide controlling the stability of the ''[[cggR]]-[[gapA]]'' mRNA <br/><br/>

{| align="right" border="1" cellpadding="2" 
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''sr1''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ykzW ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || [[small RNAs|small regulatory RNA]]/ regulatory peptide
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || control of arginine metabolism and glycolysis
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this peptide in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/YkzW YkzW]
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 4.4 kDa, 3.89
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 205 bp (RNA), 120 bp (ORF), 39 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[slp]]'', ''[[speA]]''
|-
|style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/sr1_nucleotide.txt     Gene sequence         ]''' 
|style="background:#FAF8CC;" align="center"|
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:sr1_context.gif]]
|-
|}

__TOC__

<br/><br/><br/>

	
= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[biosynthesis/ acquisition of amino acids]]}},
{{SubtiWiki category|[[utilization of amino acids]]}},
{{SubtiWiki category|[[ncRNA]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[CcpN regulon]]}}

=The [[SR1 regulon]]: ''[[ahrC]]''=

=The gene=

=== Basic information ===

* '''Locus tag:'''

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' no entry

=== Additional information===
Located between the ''[[slp]]'' and ''[[speA]]'' genes.




=The RNA=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' hybridizes to ''[[ahrC]]'' mRNA and inhibits [[AhrC]] translation. [http://www.ncbi.nlm.nih.gov/sites/entrez/17020585 PubMed]

=== Extended information on the RNA===

* '''Kinetic information'''	

* '''Interactions:''' Binds ''[[ahrC]]'' mRNA [http://www.ncbi.nlm.nih.gov/sites/entrez/17020585 PubMed]

* '''Localization'''

=== Database entries ===

* '''Structure''': 

=== Additional information===

Information on the structure of the RNA can be found in [http://www.ncbi.nlm.nih.gov/pubmed/17020585?ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum Heidrich ''et al''., 2006 ]

=The peptide=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' the peptide controls the stability of the ''[[cggR]]-[[gapA]]'' mRNA {{PubMed|20444087}}

* '''Protein family:''' the peptide is conserved in bacilli

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''	

* '''Domains:''' 

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:''' 
** [[GapA]]-[[YkzW]] {{PubMed|20444087}}

* '''Localization:'''

=== Database entries ===

* '''Structure:'''	

* '''UniProt:''' [http://www.uniprot.org/uniprot/C0H410 C0H410]

* '''KEGG entry:'''

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=

* '''Operon:''' sr1 [http://www.ncbi.nlm.nih.gov/sites/entrez/16164558 PubMed]

* '''Sigma factor:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/16164558 PubMed]

* '''Regulation:''' Repressed in the presence of glucose by [[CcpN]] [http://www.ncbi.nlm.nih.gov/sites/entrez/16164558 PubMed]

* '''Regulatory mechanism:''' transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/16164558 PubMed]

* '''Additional information:'''

=Biological materials =

* '''Mutant:''' 168 sr1::cat, available in [[Brantl]] lab

* '''Expression vector:'''
	
* '''lacZ fusion:'''

=Labs working on this gene/protein=

[[Sabine Brantl |Sabine Brantl]], Bacterial Genetics, Friedrich-Schiller-University of Jena, Germany [http://www.uni-jena.de/AG_Bakteriengenetik_(_Doz__Dr__Sabine_Brantl_).html homepage]

=Your additional remarks=

=References=

<pubmed>16164558 17020585 17576690, 20444087 </pubmed>

[[Category:Protein-coding genes]]