View source for Fbp

* '''Description:''' fructose-1,6-bisphosphatase, involved in gluconeogenesis <br/><br/>

{| align="right" border="1" cellpadding="2" 
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''fbp''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''fdp, yydE ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no 
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || fructose-1,6-bisphosphatase
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || gluconeogenesis 
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism], [http://subtiwiki.uni-goettingen.de/pathways/carbohydrate_metabolic_pathways.html Sugar catabolism]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 77 kDa, 5.601  
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 2013 bp, 671 aa 
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yydF]]'', ''[[yydD]]''
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB16056&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:fbp_context.gif]]
 <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|}

__TOC__

<br/><br/><br/><br/><br/><br/>

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU40190

===Phenotypes of a mutant ===

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/fbp.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11478]

=== Additional information===


=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' D-fructose 1,6-bisphosphate + H<sub>2</sub>O = D-fructose 6-phosphate + phosphate (according to Swiss-Prot) 

* '''Protein family:''' FBPase class 3 family (according to Swiss-Prot)

* '''Paralogous protein(s):'''

=== Extended information on the protein ===

* '''Kinetic information:'''	

* '''Domains:''' 

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''Interactions:'''

* '''Localization:'''

=== Database entries ===

* '''Structure:''' [http://www.pdb.org/pdb/explore/explore.do?structureId=3D1R 3D1R]  (from ''E. coli'', 49% identity, 68% similarity)	

* '''UniProt:''' [http://www.uniprot.org/uniprot/Q45597 Q45597]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU40190]

* '''E.C. number:''' [http://www.expasy.org/enzyme/3.1.3.11 3.1.3.11]

=== Additional information===

=Expression and regulation=

* '''Operon:''' ''fpb'' {{PubMed|9696785}}

* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|9696785}}

* '''Regulation:''' 

* '''Regulatory mechanism:''' 

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''
        
* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:''' 

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>6257649,221467,9696785,, </pubmed>

[[Category:Protein-coding genes]]