yqjD

yqjD
168

propionyl-CoA carboxylase

Locus
BSU_23920
Molecular weight
55.12 kDa
Isoelectric point
9.09
Protein length
507 aaSequenceBlast
Gene length
1524 bpSequenceBlast
Function
lipid metabolism
Product
propionyl-CoA carboxylase
Essential
no
E.C.
6.4.1.3
Synonyms
yqjD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG4799 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,486,813 → 2,488,336
The protein
Catalyzed reaction/ biological activity
ATP + hydrogencarbonate + propanoyl-CoA --> (S)-methylmalonyl-CoA + ADP + H+ + phosphate (according to UniProt)
Protein family
AccD/PCCB family (with AccD and YngE, according to UniProt)
Domains
CoA carboxyltransferase N-terminal domain (aa 1-254) (according to UniProt)
CoA carboxyltransferase C-terminal domain (aa 256-501) (according to UniProt)
Structure
1VRG (PDB) (from Thermotoga maritima, 57% identity)
P54541 (AlphaFold)
Paralogous protein(s)
YngE
Biological materials
Mutant
MGNA-C387 (yqjD::erm), available at the NBRP B. subtilis, Japan
BKE23920 (ΔyqjD::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTTCGTGTAAAAATGATCCA,  downstream forward: _UP4_CTTTAATATGGAGGGACTTA
BKK23920 (ΔyqjD::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTTCGTGTAAAAATGATCCA,  downstream forward: _UP4_CTTTAATATGGAGGGACTTA
References
Research papers
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Time of last update: 2025-03-27 14:00:24

Author of last update: Jstuelk