nagZ
168

N-acetylglucosaminidase

Locus

BSU_01660

Molecular weight

70.40 kDa

Isoelectric point

9.76

Protein length

642 aaSequenceBlast

Gene length

1929 bpSequenceBlast

Function

cell wall recycling

Product

N-acetylglucosaminidase

Essential

E.C.

3.2.1.52

Synonyms

nagZ, yzbA, ybbD

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

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Categories containing this gene/protein

Cellular processes, Cell envelope and cell division, Cell wall degradation/ turnover, Utilization of cell wall components

List of homologs in different organisms, belongs to COG1472 (Galperin et al., 2021)

This gene is a member of the following regulons

MurR regulon

Gene

Coordinates

186,452 188,380

Phenotypes of a mutant

increased autolysis PubMed

The protein

Catalyzed reaction/ biological activity

cleaves muropeptides derived from peptidoglycan, but not peptidoglycan itself PubMed

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides (according to UniProt)

Protein family

glycosyl hydrolase 3 family (single member, according to UniProt)

Structure

3BMX (PDB) PubMed

P40406 (AlphaFold)

Localization

secreted (with signal peptide), remains to some extent cell wall-associated PubMed

Additional information

The gene is mis-annotated in KEGG as an ortholog of beta-N-acetylhexosaminidase EC 3.2.1.52. It is marked in MetaCyc as similar to beta-hexosaminidase. No EC annotation is available in Swiss-ProtSwiss-Prot.supporting the annotation is available. PubMed

Expression and Regulation

Operons

Genes

murQ-murR-murP-amiE-nagZ-namZ

Description

PubMed

Regulation

expressed in late exponential and early stationary phase PubMed

Regulatory mechanism

MurR: repression, PubMed, in murR regulon

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Biological materials