trmD

trmD
168

tRNA methyltransferase, methylates G37 residue at the N1 position in a subset of tRNAs

Locus
BSU_16030
Molecular weight
27.56 kDa
Isoelectric point
5.31
Protein length
243 aaSequenceBlast
Gene length
732 bpSequenceBlast
Function
tRNA modification
Product
tRNA methyltransferase
Essential
yes
E.C.
2.1.1.31
Synonyms
trmD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0336 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,675,171  1,675,902
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
guanosine37 in tRNA + S-adenosyl-L-methionine --> H+ + N1-methylguanosine37 in tRNA + S-adenosyl-L-homocysteine (according to UniProt)
Protein family
RNA methyltransferase trmD family (single member, according to UniProt)
Structure
3KY7 (PDB) (from Staphylococcus aureus, 62% identity)
O31741 (AlphaFold)
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
ylxM-ffh-rpsP-khpA-ylqD-rimM-trmD-rplS
Description
PubMed
Regulation
the mRNA is processed between ffh and rpsP by RNase Y, this requires the RicA-RicF-RicT complex PubMed
Expression
expression is decreased upon depletion of tRNA maturation factors rnpB or rnz PubMed
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

ylxM→rplS

2025-03-25 19:19:11

Jstuelk

122

4F2FF9A3B937EE85312D0B0F9DA494E4B44E2297

417C7007C2492335257F8AEF606BB8627753757F

Genes
rpsP-khpA-ylqD-rimM-trmD-rplS
Description
PubMed
Open in new tab

rpsP→rplS

2025-03-17 20:15:37

Jstuelk

64

B00427AA69EF576CAC3B8B5C44347F99001CAF0D

B00427AA69EF576CAC3B8B5C44347F99001CAF0D

References
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885ECD9FAAC8BC95D32F049825D6B6244C046112

Page visits: 2425

Time of last update: 2025-03-31 20:03:32

Author of last update: Jstuelk