sbcC

sbcC
168

DNA exonuclease

Locus
BSU_10650
Molecular weight
128.70 kDa
Isoelectric point
5.29
Protein length
1130 aaSequenceBlast
Gene length
3393 bpSequenceBlast
Function
DNA inter-strand cross-link repair
Product
DNA exonuclease
Essential
no
Synonyms
sbcC, yirY
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0419 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,144,749 → 1,148,141
Phenotypes of a mutant
reduced resistance towards electron beams PubMed
The protein
Protein family
SMC family (with Smc, according to UniProt)
Structure
6S6V (PDB) (from E. coli, corresponds to aa 1 ... 622, 27% identity) PubMed
O06714 (AlphaFold)
Localization
Nucleoid (Mid-cell) PubMed
Expression and Regulation
Operons
Genes
addB-addA-sbcD-sbcC-hlpB
Description
PubMed
Regulation
positive control by ComK PubMed
Regulatory mechanism
ComK: activation, in comK regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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addB→hlpB

2025-04-03 11:44:12

ghost

168

045c7bb396e5f5521fcc2041130afbaac29b0bd8

E5051999C31DBE142375FC331C2F21A76C29910D

Biological materials
Mutant
MGNA-B290 (yirY::erm), available at the NBRP B. subtilis, Japan
GP894 (sbcD-sbcC::kan), available in Jörg Stülke's lab PubMed
1A898 ( sbcC::cat), PubMed, available at BGSC
BKE10650 (ΔsbcC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CTTAATGCTTAAGGCGATCG,  downstream forward: _UP4_GAGTTGATGTAAGGGAGGAG
BKK10650 (ΔsbcC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CTTAATGCTTAAGGCGATCG,  downstream forward: _UP4_GAGTTGATGTAAGGGAGGAG
Labs working on this gene/protein
Peter Graumann, Freiburg University, Germany homepage
References
Reviews
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Original Publications
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ED825D5B3290BA8F9C92477B1FCC433ADB3C8449

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Time of last update: 2025-04-03 12:31:51

Author of last update: Jstuelk