rsbR
168

stressosome sensor protein, control of SigB activity

Locus

BSU_04670

Molecular weight

30.90 kDa

Isoelectric point

4.73

Protein length

274 aaSequenceBlast

Gene length

825 bpSequenceBlast

Function

control of SigB activity

Product

activator of RsbT kinase activity, stressosome sensor protein

Essential

Synonyms

rsbR, ycxR, rsbRA

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1366 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

519,408 520,232

Phenotypes of a mutant

the mutant tends to acquire suppressor mutations that result in improved growth PubMed

The protein

Catalyzed reaction/ biological activity

positive regulator of YtvA-dependent light activation of the SigB stress response PubMed

phosphorylated RsbR activates the kinase activity of RsbT PubMed

Domains

RsbRA is composed of an N-terminal nonheme globin domain and a highly conserved C-terminal STAS (Sulphate Transporter and AntiSigma factor antagonist) domain. The C-terminal STAS domain is the target of the serine/threonine-specific kinase RsbT (see below).

STAS domain (aa 150-265) (according to UniProt)

Structure

2BNL (PDB) (N-terminal domain), 3VY9 (PDB) (complete stressosome)

P42409 (AlphaFold)

Modification

phosphorylation on Thr-171 and Thr-205 by RsbT PubMed

Paralogous protein(s)

YtvA, RsbRD, RsbRB, RsbRC

Additional information

belongs to the 100 most abundant proteins PubMed

Expression and Regulation

Operons